Novus Scientific, Rapsgatan 25, Uppsala, Sweden
Hernia. 2012 Apr;16(2):191-7. doi: 10.1007/s10029-011-0885-y. Epub 2011 Oct 5.
The purpose of this study was to evaluate the biocompatibility, local tissue effects and performance of a synthetic long-term resorbable test mesh (TIGR(®) Matrix Surgical Mesh) compared to a non-resorbable polypropylene control mesh following implantation in a sheep model.
Full-thickness abdominal wall defects were created in 14 sheep and subsequently repaired using test or control meshes. Sacrifices were made at 4, 9, 15, 24 and 36 months and results in terms of macroscopic observations, histology and collagen analysis are described for 4, 9, 15, 24 and 36 months.
The overall biocompatibility was good, and equivalent in the test and control meshes while the resorbable mesh was characterized by a collagen deposition more similar to native connective tissue and an increased thickness of the integrating tissue. The control polypropylene mesh provoked a typical chronic inflammation persistent over the 36-month study period. As the resorbable test mesh gradually degraded it was replaced by a newly formed collagen matrix with an increasing ratio of collagen type I/III, indicating a continuous remodeling of the collagen towards a strong connective tissue. After 36 months, the test mesh was fully resorbed and only microscopic implant residues could be found in the tissue.
This study suggests that the concept of a long-term resorbable mesh with time-dependent mechanical characteristics offers new possibilities for soft tissue repair and reinforcement.
本研究旨在评估一种合成的长期可吸收试验网（TIGR®Matrix 外科网）与不可吸收的聚丙烯对照网在羊模型中的生物相容性、局部组织效应和性能。
在 14 只羊的全层腹壁缺损处植入试验或对照网，然后进行修复。在 4、9、15、24 和 36 个月时进行牺牲，并描述了 4、9、15、24 和 36 个月的宏观观察、组织学和胶原分析结果。
整体生物相容性良好，试验网和对照网相当，而可吸收网的特点是胶原沉积更类似于天然结缔组织，整合组织的厚度增加。对照的聚丙烯网引起了典型的慢性炎症，持续了 36 个月的研究期。随着可吸收的试验网逐渐降解，它被一个新形成的胶原基质所取代，胶原 I/III 的比例增加，表明胶原不断向强结缔组织重塑。36 个月后，试验网完全吸收，组织中仅发现微小的植入物残留。
本研究表明，具有时间依赖性机械特性的长期可吸收网的概念为软组织修复和增强提供了新的可能性。
