Animal Science Department, University of California, Davis, CA 95616, USA.
J Biochem Mol Toxicol. 2012 Jan;26(1):31-4. doi: 10.1002/jbt.20410. Epub 2011 Oct 3.
Pyridostigmine bromide (PB) has been used to protect soldiers from the toxic effects of soman, a chemical warfare agent. Recent research shows that pyridostigmine bromide protects a significant percentage of acetylcholinesterase in isolated human intercostal muscle. Findings presented here indicate that red blood cell acetylcholinesterase is similarly protected by pyridostigmine bromide from the action of diisopropyl fluorophosphate and several organophosphate pesticides including chlorpyrifos-oxon, diazinon-oxon, and paraoxon, but not malaoxon, using the bovine red blood cell as a subject. These findings suggest that pretreatment with PB may protect growers, farmworkers, first responders, and the public, in general, from the effects of selected pesticides.
溴化吡斯的明（PB）被用于保护士兵免受梭曼（一种化学战剂）的毒性影响。最近的研究表明，溴化吡斯的明可保护分离的人肋间肌中乙酰胆碱酯酶的很大一部分。本文的研究结果表明，红细胞乙酰胆碱酯酶也可以通过溴化吡斯的明得到保护，使其免受二异丙基氟磷酸和几种有机磷农药（包括氯吡硫磷-氧、二嗪农-氧和对氧磷）的作用，而马拉硫磷则不受影响，实验以牛红细胞作为研究对象。这些发现表明，使用 PB 进行预处理可能会保护种植者、农场工人、急救人员以及一般公众免受选定农药的影响。
