Animal Science Department, University of California-Davis, Davis, CA 95616, USA.
J Biochem Mol Toxicol. 2012 Dec;26(12):506-9. doi: 10.1002/jbt.21456. Epub 2012 Nov 20.
The carbamate pyridostigmine bromide has been used as a pretreatment to protect individuals from the nerve agent soman. Previous research showed that pyridostigmine significantly protected human muscle acetylcholinesterase in vitro from soman and bovine red blood cell acetylcholinesterase from some organophosphorous pesticides. Research presented here demonstrates that pretreatment with other carbamates also protects acetylcholinesterase from inhibition by the pesticides chlorpyrifos-oxon and diazinon-oxon, but not from malaoxon.
氨基甲酸酯类化合物溴化吡斯的明被用作一种预处理剂，以保护个体免受神经毒剂梭曼的伤害。先前的研究表明，吡斯的明可显著保护人肌肉乙酰胆碱酯酶免受梭曼的抑制，保护牛红细胞乙酰胆碱酯酶免受某些有机磷农药的抑制。这里介绍的研究表明，用其他氨基甲酸酯预处理也可以保护乙酰胆碱酯酶免受氯氧磷-氧、二嗪磷-氧的抑制，但不能免受马拉氧磷的抑制。
