慢性免疫性血小板减少症患者的 IL-17A 水平和 Th17 细胞分化相关细胞因子的水平升高。
The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia.
机构信息
Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
出版信息
Haematologica. 2011 Oct;96(10):1560-4. doi: 10.3324/haematol.2011.046417.
Abstract
Th17 cells have been associated with immune-mediated diseases in humans but it has still not been determined whether they play a role in immune thrombocytopenia. We evaluated representative cytokines of the Th17, Th1, Th2 and Treg cell commitment in the serum of patients with chronic immune thrombocytopenia, as well as the cell source of IL-17A. Higher levels of IL-17A and Th17-related cytokines, and an increased percentage of IL-17A producing CD4+ and neutrophils were observed in patients. The levels of cytokines involved in Th1 cell commitment IFN-γ, IL-2, IL12-p70 and the percentages of Th1 cells were also increased, but IL-4 was not detected. Although the concentrations of IL-10 were higher, the levels of TGF-β were similar in both groups. In conclusion, our results point to a putative role for Th-17 cells/IL-17A cytokine in the pathogenesis of chronic immune thrombocytopenia.
摘要
Th17 细胞与人类免疫介导的疾病有关，但尚未确定它们是否在免疫性血小板减少症中发挥作用。我们评估了慢性免疫性血小板减少症患者血清中 Th17、Th1、Th2 和 Treg 细胞定向的代表性细胞因子，以及 IL-17A 的细胞来源。患者的 IL-17A 和 Th17 相关细胞因子水平升高，以及产生 IL-17A 的 CD4+ 和中性粒细胞的百分比增加。参与 Th1 细胞定向的细胞因子 IFN-γ、IL-2、IL12-p70 的水平也升高，但未检测到 IL-4。尽管 IL-10 的浓度较高，但两组的 TGF-β 水平相似。总之，我们的结果表明 Th-17 细胞/IL-17A 细胞因子可能在慢性免疫性血小板减少症的发病机制中发挥作用。
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