Br J Psychiatry. 2011 Apr;198(4):250-2. doi: 10.1192/bjp.bp.110.085068.
Cognitive impairment is a core feature of schizophrenia. Evidence in this Journal suggests that disrupted circadian synchronisation of sleep-wake phases may be one cause. Circadian synchronisation depends on the external input of light-dark cues and the integrity of central nervous system circadian oscillators; these may represent new interventional targets to improve cognition.
认知障碍是精神分裂症的核心特征。本杂志中的证据表明，睡眠-觉醒节律的昼夜同步失调可能是其中一个原因。昼夜同步依赖于光-暗线索的外部输入和中枢神经系统昼夜节律振荡器的完整性；这些可能代表改善认知功能的新干预靶点。
