Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
Diabetes Care. 2011 Dec;34(12):2542-4. doi: 10.2337/dc11-1199. Epub 2011 Oct 4.
To examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D).
This was a population-based retrospective cohort study. Cox regression, stratified by pre- (<55 years) and postmenopausal (≥55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0-3 months) and later (3 months to 10 years) time windows after diabetes index date.
Compared with women without T2D, HRs for breast cancer were 0.95 (95% CI 0.48-1.86; P = 0.88) and 1.31 (0.92-1.86; P = 0.14) in pre- and postmenopausal women with T2D, respectively, in the early time window, and 0.92 (0.75-1.13; P = 0.45) and 1.00 (0.90-1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window.
We observed a trend toward an increased risk of breast cancer in postmenopausal women with T2D, but only in the time period immediately after diabetes index date.
探讨 2 型糖尿病（T2D）绝经前和绝经后妇女罹患乳腺癌的风险。
这是一项基于人群的回顾性队列研究。采用 Cox 回归，按绝经前（<55 岁）和绝经后（≥55 岁）分层，分别估计糖尿病指数日期后早期（0-3 个月）和晚期（3 个月至 10 年）时间窗内乳腺癌的风险比（HR）。
与无 T2D 的女性相比，T2D 绝经前女性的乳腺癌 HR 在早期时间窗内分别为 0.95（95%CI 0.48-1.86；P=0.88）和 1.31（0.92-1.86；P=0.14），T2D 绝经后女性分别为 0.92（0.75-1.13；P=0.45）和 1.00（0.90-1.11；P=0.93）；在晚期时间窗内，T2D 绝经前和绝经后女性的 HR 分别为 0.95（0.75-1.21；P=0.69）和 1.00（0.90-1.11；P=0.98）。
我们观察到 T2D 绝经后妇女罹患乳腺癌的风险呈增加趋势，但仅在糖尿病指数日期后立即出现。
