Bae Jong Myon
Department of Preventive Medicine, Jeju National University College of Medicine, Jeju, Korea.
J Menopausal Med. 2020 Apr;26(1):29-33. doi: 10.6118/jmm.19014.
Previous quantitative systematic reviews conducting subgroup analyses by race have reported that the association between diabetes and breast cancer in Asian women was inconclusive. The aim of this meta-epidemiological study (MES) was to evaluate this association from additional population-based cohort studies.
The potential subjects of this MES were six Asian cohort studies selected by previous systematic reviews. Additional reports were found from the selected articles using citation discovery tools. The study with the longest follow-up period was selected among prospective studies of the same cohorts. A summary relative risk (sRR) and its 95% confidence intervals (CI) were calculated using random effect models.
Four cohort studies on Asian women were finally selected. The participants were from the women population of Korea, Japan, China, and Taiwan and included a total of 1,448,254 women. The sRR (95% CI) (I-squared value) was 1.20 (0.98-1.46) (63.1%).
This MES found that the history of diabetes mellitus was not associated with the risk of breast cancer in Asian women. As breast cancer in this population develops at a younger age, additional cohort studies are necessary to conduct a subgroup analysis by menopausal status at diagnosis of breast cancer in Asian women.
以往按种族进行亚组分析的定量系统评价报告称，亚洲女性糖尿病与乳腺癌之间的关联尚无定论。本Meta流行病学研究（MES）的目的是通过更多基于人群的队列研究来评估这种关联。
本MES的潜在研究对象是先前系统评价筛选出的6项亚洲队列研究。使用引文发现工具从所选文章中查找其他报告。在同一队列的前瞻性研究中选择随访期最长的研究。采用随机效应模型计算汇总相对风险（sRR）及其95%置信区间（CI）。
最终选取了4项关于亚洲女性的队列研究。参与者来自韩国、日本、中国和台湾的女性人群，共计1,448,254名女性。sRR（95%CI）（I²值）为1.20（0.98 - 1.46）（63.1%）。
本MES发现，糖尿病病史与亚洲女性乳腺癌风险无关。由于该人群乳腺癌发病年龄较轻，有必要开展更多队列研究，以便按亚洲女性乳腺癌诊断时的绝经状态进行亚组分析。
