Ehrmann R L, Weidner N, Welch W R, Gleiberman I
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Int J Gynecol Pathol. 1990;9(3):272-82. doi: 10.1097/00004347-199007000-00007.
We report a unique carcinosarcoma of the ovary having an organoid growth pattern that resembled immature teratoma. The tumor contained both adenocarcinoma and squamous carcinoma (focally sebaceous) admixed with chondrosarcoma, rhabdomyosarcoma, and malignant neuroectodermal components. The neuroectodermal components were prominent, resembling ependymoblastoma, medulloepithelioma, ganglioneuroblastoma, glioblastoma multiforme, and pigmented neuroectodermal tumor. Immunohistochemical studies dramatically revealed carcinoma and rhabdomyosarcoma admixed with malignant neuroectodermal tumor. Implants of papillary serous carcinoma (with psammoma bodies) were present in the opposite ovary, uterine serosa, omentum, and appendiceal serosa. Although a variant not previously described in the ovary, this ovarian carcinosarcoma closely resembled nasopharyngeal tumors described as teratoid carcinosarcoma or terato-carcinosarcoma.
我们报告了一例独特的卵巢癌肉瘤，其具有类似未成熟畸胎瘤的器官样生长模式。肿瘤包含腺癌和鳞状癌（局灶性皮脂腺样），并混有软骨肉瘤、横纹肌肉瘤和恶性神经外胚层成分。神经外胚层成分显著，类似室管膜母细胞瘤、髓上皮瘤、神经节神经母细胞瘤、多形性胶质母细胞瘤和色素性神经外胚层肿瘤。免疫组织化学研究显著显示癌和横纹肌肉瘤与恶性神经外胚层肿瘤混合存在。对侧卵巢、子宫浆膜、大网膜和阑尾浆膜存在乳头状浆液性癌（伴有砂粒体）种植灶。尽管这是一种先前未在卵巢中描述过的变异型，但这种卵巢癌肉瘤与被描述为畸胎样癌肉瘤或畸胎癌肉瘤的鼻咽肿瘤极为相似。
