Aoki Masato, Takaya Hisamitsu, Otani Tomoyuki, Nakai Hidekatsu, Murakami Kosuke, Matsumura Noriomi
Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, 377-2, Ohno-higashi, Osakasayama, Osaka Japan.
Department of Pathology, Kindai University Faculty of Medicine, Osakasayama, Osaka Japan.
Int Cancer Conf J. 2022 Aug 8;11(4):231-237. doi: 10.1007/s13691-022-00571-w. eCollection 2022 Oct.
Ovarian teratoid carcinosarcoma involves an epithelial tumor of the Müllerian duct and an immature neuroepithelium, which is a characteristic of immature teratomas. Here, we describe the case of a 60-year-old woman who underwent surgery for a stage IC3 ovarian malignancy. The tumor showed a variety of histological features, including clear cell carcinoma, immature teratoma, and rhabdomyosarcoma, and a PIK3CA mutation was detected at the same locus in each. Two months after surgery and before the start of chemotherapy, multiple bone and liver metastases were found. Four courses of combination therapy with vincristine, actinomycin D and cyclophosphamide, the standard chemotherapy regimen for pediatric rhabdomyosarcoma, were administered, and a complete response was achieved. After a 2-month rest period, the patient developed recurrent peritoneal dissemination and underwent 6 courses of paclitaxel, carboplatin, and bevacizumab chemotherapy, resulting in a partial response. This is the eighth reported case of ovarian teratoid carcinosarcoma. This tumor has a very aggressive course, but initially responds to chemotherapy. However, survival over 5 years has not been reported, and elucidation of the pathogenesis and development of new treatment methods are needed.
The online version contains supplementary material available at 10.1007/s13691-022-00571-w.
卵巢畸胎样癌肉瘤累及苗勒管上皮肿瘤和未成熟神经上皮，这是未成熟畸胎瘤的特征。在此，我们描述一例60岁女性，她因IC3期卵巢恶性肿瘤接受了手术。肿瘤呈现多种组织学特征，包括透明细胞癌、未成熟畸胎瘤和横纹肌肉瘤，且在每个肿瘤中相同位点均检测到PIK3CA突变。术后两个月且在化疗开始前，发现多发骨和肝转移。给予小儿横纹肌肉瘤的标准化疗方案长春新碱、放线菌素D和环磷酰胺联合治疗四个疗程，取得完全缓解。经过2个月的休息期后，患者出现复发性腹膜播散，并接受了六个疗程的紫杉醇、卡铂和贝伐单抗化疗，获得部分缓解。这是第八例报道的卵巢畸胎样癌肉瘤病例。该肿瘤病程极具侵袭性，但最初对化疗有反应。然而，尚未有超过5年生存的报道，需要阐明其发病机制并开发新的治疗方法。
在线版本包含可在10.1007/s13691-022-00571-w获取的补充材料。
