The Wilmer Eye Institute, Green Spring Station, Lutherville, MD 21093, USA.
J Refract Surg. 2011 Sep;27(9):686-90. doi: 10.3928/1081597X-20110324-01.
To report the results of photorefractive keratectomy (PRK) in patients with pigment dispersion syndrome.
The pre- and postoperative records of patients with pigment dispersion syndrome who underwent PRK between January 2002 and March 2009 were reviewed. Data for analysis included gender, age, ablation depth, surgical complications, manifest refraction spherical equivalent, uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), intraocular pressure (IOP), central corneal thickness (CCT), cup-to-disc (c/d) ratio, and postoperative complications.
Thirty-seven eyes of 19 patients (17 men and 2 women) with a mean age of 37.5 ± 6.9 years were included for review. At final follow-up, mean 404.1±119.5 days postoperative, UDVA was 20/15 or better in 67.6%, 20/20 or better in 91.9%, and 20/25 or better in 100% of eyes; 94.6% of eyes were within 0.50 diopters (D) and 100% were within 1.00 D of emmetropia. Corrected distance visual acuity was unchanged from preoperative in 73% and improved by one line in 27% of eyes. No eye lost 1 or more lines of CDVA. When corrected for change in CCT and curvature, mean postoperative IOP was elevated from baseline (16.7 ± 3.8 mmHg) at 1 month (18.1 ± 4.9 mmHg, P =.044) but unchanged at any other time postoperatively. Two (11%) of 19 patients were steroid responders, requiring a single topical agent until completing the course of steroids. No significant change was noted in mean c/d ratio from baseline (0.35±0.12) to final postoperative (0.35 ± 0.13, P = .99).
Although PRK in patients with pigment dispersion syndrome resulted in excellent UDVA, retention of CDVA, and low incidence of adverse effects 1 to 2 years after surgery, long-term safety and efficacy outcomes of PRK in this cohort remain speculative
报告行准分子激光角膜切削术（PRK）治疗色素播散综合征患者的结果。
对 2002 年 1 月至 2009 年 3 月期间行 PRK 治疗的色素播散综合征患者的术前和术后记录进行了回顾。分析的数据包括性别、年龄、消融深度、手术并发症、视力矫正等效球镜、未矫正远视力（UDVA）、矫正远视力（CDVA）、眼压（IOP）、中央角膜厚度（CCT）、杯盘比（c/d）和术后并发症。
19 例患者（17 名男性和 2 名女性）的 37 只眼纳入研究，平均年龄为 37.5±6.9 岁。末次随访时，术后平均 404.1±119.5 天，67.6%的眼 UDVA 为 20/15 或更好，91.9%的眼为 20/20 或更好，100%的眼为 20/25 或更好；94.6%的眼屈光度在 0.50 屈光度（D）以内，100%的眼屈光度在 1.00 D 以内。73%的眼术后 CDVA 与术前相比无变化，27%的眼提高了一行。没有眼视力下降 1 行或更多。校正 CCT 和曲率的变化后，术后 1 个月时平均 IOP 从基线（16.7±3.8mmHg）升高至 18.1±4.9mmHg（P=.044），但此后任何时间均无变化。19 例患者中有 2 例（11%）为类固醇反应者，需要单一局部药物治疗，直至完成类固醇疗程。平均 c/d 比值从基线（0.35±0.12）到最终术后（0.35±0.13，P=0.99）没有明显变化。
虽然色素播散综合征患者行 PRK 治疗后 1 至 2 年获得了极好的 UDVA、保持了 CDVA 且不良反应发生率低，但该队列中 PRK 的长期安全性和疗效仍存在推测性。
