van der Rest C, Cavalier E, Colson L, Kaux J-F, Krzesinski J-M, Reginster J-Y, Hustinx R, Delanaye P
Département de médecine nucléaire, CHU Sart-Tilman, Université de Liège, Liège, Belgique.
Rev Med Suisse. 2011 Aug 31;7(306):1630-3.
In this article, we will discuss about hypophosphatemia due to tumor-induced osteomalacia. This disease is characterized by severe muscular and articular tenderness inducing profound walking limitation. Clinical chemistry results show severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) is abnormally high. Physiological role of FGF-23 is examined. We also consider the pathophysiology of tumor induced osteomalacia, the use of different investigations to localize the tumor and therapies available to treat this rare disease.
在本文中，我们将讨论肿瘤诱导的骨软化症所致的低磷血症。这种疾病的特征是严重的肌肉和关节压痛，导致严重的行走受限。临床化学结果显示，由于高磷尿症导致严重的低磷血症。成纤维细胞生长因子23（FGF - 23）异常升高。我们研究了FGF - 23的生理作用。我们还考虑了肿瘤诱导的骨软化症的病理生理学、使用不同检查来定位肿瘤以及治疗这种罕见疾病的可用疗法。
