肿瘤性骨软化症：肿瘤可能隐匿难寻！

Tumor-induced osteomalacia: The tumor may stay hidden!

机构信息

Department of Nuclear Medicine, University of Liège, CHU Sart Tilman, Liège, Belgium.

出版信息

Clin Biochem. 2011 Oct;44(14-15):1264-6. doi: 10.1016/j.clinbiochem.2011.07.013. Epub 2011 Aug 6.

DOI:10.1016/j.clinbiochem.2011.07.013

Abstract

We report the case of a patient with severe muscular and articular tenderness that caused almost complete immobility. This subject had severe hypophosphatemia due to hyperphosphaturia. Fibroblast growth factor 23 (FGF-23) was abnormally high and the diagnostic of tumor-induced osteomalacia was made. Despite multiple tests, the tumor was not localized. In this report, we discuss different possible investigations to localize the tumor. Lastly, we review the potential therapy available when tumor is not found and can thus not be excised.

摘要

我们报告了一例严重肌肉和关节压痛的患者，几乎导致完全不能活动。该患者由于高磷血症而出现严重的低磷血症。成纤维细胞生长因子 23（FGF-23）异常升高，诊断为肿瘤性骨软化症。尽管进行了多项检查，但肿瘤仍未定位。在本报告中，我们讨论了定位肿瘤的不同可能的检查方法。最后，我们回顾了在肿瘤未找到且无法切除时可采用的潜在治疗方法。