南半球多发性硬化症活动的月度变化：来自巴西 996 例复发的分析。
Monthly variation of multiple sclerosis activity in the southern hemisphere: analysis from 996 relapses in Brazil.
机构信息
Department of Neurology, University of Campinas, Campinas, Brazil.
出版信息
Eur J Neurol. 2012 Apr;19(4):660-2. doi: 10.1111/j.1468-1331.2011.03543.x. Epub 2011 Oct 4.
BACKGROUND AND PURPOSE
Seasonal variations of multiple sclerosis (MS) activity have been reported, however, most data come from studies in the northern hemisphere.
METHODS
We reviewed medical records of MS patients living in Campinas region, Brazil. The first symptoms' date was defined as the relapse month. Climatic information included UV radiation index, median temperature, rainfall, and humidity.
RESULTS
Two hundred and nine patients were included. The incidence of relapses was highest in January (11.2%) and December (10.4%) and lowest in November (5.7%) and October (7.0%) (P < 0.015). The months with highest incidence of relapses (December-January) had higher UV radiation index and humidity rates (P = 0.032 and 0.040, respectively).
CONCLUSION
Most exacerbations were in the spring/summer transition, which also showed higher UV radiation index and humidity rate. Along with other environmental factors, seasonal fluctuation contributes to MS activity.
背景与目的
多发性硬化症（MS）的活动具有季节性变化，然而，大多数数据来自北半球的研究。
方法
我们回顾了居住在巴西坎皮纳斯地区的 MS 患者的病历。首次出现症状的日期被定义为复发月份。气候信息包括紫外线辐射指数、平均温度、降雨量和湿度。
结果
共纳入 209 例患者。复发的发生率在 1 月（11.2%）和 12 月（10.4%）最高，11 月（5.7%）和 10 月（7.0%）最低（P<0.015）。复发发生率最高的月份（12 月至 1 月）紫外线辐射指数和湿度较高（P=0.032 和 0.040）。
结论
大多数恶化发生在春季/夏季过渡期间，该时期也显示出较高的紫外线辐射指数和湿度。与其他环境因素一样，季节性波动对 MS 活动有影响。
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