Koziol James A, Feng Anne C
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
Neuroepidemiology. 2004 Sep-Oct;23(5):217-23. doi: 10.1159/000079946.
Environmental factors may be involved in the etiology of multiple sclerosis (MS). We investigate prevalence of exacerbations and MRI findings in a cohort of relapsing-remitting multiple sclerosis patients, for evidence of seasonal variation or cyclic trends. We find only weak evidence of seasonality in our data. Differences in reports of seasonal variation in multiple sclerosis disease activity may be due to regional climatic differences or other geographic variables that change with latitude as well as genetic predisposition.
环境因素可能与多发性硬化症（MS）的病因有关。我们调查了一组复发缓解型多发性硬化症患者的病情加重情况和MRI检查结果，以寻找季节性变化或周期性趋势的证据。我们在数据中仅发现了微弱的季节性证据。多发性硬化症疾病活动季节性变化报告的差异可能是由于区域气候差异或其他随纬度变化的地理变量以及遗传易感性所致。
