Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Pakistan.
Cell Prolif. 2011 Dec;44(6):508-15. doi: 10.1111/j.1365-2184.2011.00784.x. Epub 2011 Oct 4.
Prostate cancer is a serious molecular disorder that arises because of reduction in tumour suppressors and overexpression of oncogenes. The malignant cells survive within the context of a three-dimensional microenvironment in which they are exposed to mechanical and physical cues. These signals are, nonetheless, deregulated through perturbations to mechanotransduction, from the nanoscale level to the tissue level. Increasingly sophisticated interpretations have uncovered significant contributions of signal transduction cascades in governing prostate cancer progression. To dismantle the major determinants that lie beneath disruption of spatiotemporal patterns of activity, crosstalk between various signalling cascades and their opposing and promoting effects on TRAIL-mediated activities cannot be ruled out. It is important to focus on that molecular multiplicity of cancer cells, various phenotypes reflecting expression of a variety of target oncogenes, reversible to irreversible, exclusive, overlapping or linked, coexist and compete with each other. Comprehensive investigations into TRAIL-mediated mitochondrial dynamics will remain a worthwhile area for underlining causes of tumourigenesis and for unravelling interference options.
前列腺癌是一种严重的分子紊乱，是由于肿瘤抑制因子减少和癌基因过表达引起的。恶性细胞在三维微环境中存活，在这个环境中，它们会受到机械和物理信号的影响。然而，这些信号通过从纳米级到组织级的力学转导的干扰而失调。越来越复杂的解释揭示了信号转导级联在控制前列腺癌进展中的重要贡献。为了分解活动时空模式破坏下的主要决定因素，各种信号级联之间的串扰及其对 TRAIL 介导的活性的拮抗和促进作用不能排除。重要的是要关注癌细胞的分子多样性，反映各种靶癌基因表达的各种表型，可逆的到不可逆的，排他的，重叠的或关联的，共存并相互竞争。对 TRAIL 介导的线粒体动力学的综合研究将仍然是一个值得关注的领域，以强调肿瘤发生的原因，并揭示干扰选择。
