Farooqi Ammad Ahmad, Shu Chih-Wen, Huang Hurng-Wern, Wang Hui-Ru, Chang Yung-Ting, Fayyaz Sundas, Yuan Shyng-Shiou F, Tang Jen-Yang, Chang Hsueh-Wei
Institute of Biomedical and Genetic Engineering (IBGE), Islamabad 54000, Pakistan.
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.
Int J Mol Sci. 2017 Jul 14;18(7):1523. doi: 10.3390/ijms18071523.
Clinical studies and cancer cell models emphasize the importance of targeting therapies for oral cancer. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is highly expressed in cancer, and is a selective killing ligand for oral cancer. Signaling proteins in the wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt), Sonic hedgehog (SHH), and transforming growth factor β (TGFβ) pathways may regulate cell proliferation, migration, and apoptosis. Accordingly, the genes encoding these signaling proteins are potential targets for oral cancer therapy. In this review, we focus on recent advances in targeting therapies for oral cancer and discuss the gene targets within TRAIL, Wnt, SHH, and TGFβ signaling for oral cancer therapies. Oncogenic microRNAs (miRNAs) and tumor suppressor miRNAs targeting the genes encoding these signaling proteins are summarized, and the interactions between Wnt, SHH, TGFβ, and miRNAs are interpreted. With suitable combination treatments, synergistic effects are expected to improve targeting therapies for oral cancer.
临床研究和癌细胞模型强调了口腔癌靶向治疗的重要性。肿瘤坏死因子相关凋亡诱导配体（TRAIL）在癌症中高表达，是口腔癌的选择性杀伤配体。无翅型小鼠乳腺肿瘤病毒（MMTV）整合位点家族（Wnt）、音猬因子（SHH）和转化生长因子β（TGFβ）信号通路中的信号蛋白可能调节细胞增殖、迁移和凋亡。因此，编码这些信号蛋白的基因是口腔癌治疗的潜在靶点。在本综述中，我们聚焦于口腔癌靶向治疗的最新进展，并讨论TRAIL、Wnt、SHH和TGFβ信号通路中用于口腔癌治疗的基因靶点。总结了靶向编码这些信号蛋白基因的致癌性微小RNA（miRNA）和抑癌miRNA，并阐释了Wnt、SHH、TGFβ与miRNA之间的相互作用。通过合适的联合治疗，有望产生协同效应以改善口腔癌的靶向治疗。
