Lee S J, Francis H L, Awadzi K, Ottesen E A, Nutman T B
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
J Infect Dis. 1990 Aug;162(2):529-33. doi: 10.1093/infdis/162.2.529.
To define the changes in antibody response to Onchocerca volvulus antigens after treatment of patients with onchocerciasis, IgG and IgE antibodies were examined quantitatively and qualitatively in 21 patients and 3 control individuals before and sequentially for 14 days after treatment with diethylcarbamazine. The quantitative levels of IgE and IgG responses (both polyclonal and O. volvulus-specific) remained essentially unchanged for all patients, but 9 of the 21 patients showed intensified responses to one or more parasite-specific antigens, and 8 of 21 developed antibodies to previously undetected antigens. There was a significant correlation between the intensities of infection and the development of newly recognized anti-O. volvulus antibodies. These studies demonstrate that O. volvulus-specific IgE and IgG antibody responses are, at least transiently, enhanced by treatment with diethylcarbamazine and that after treatment, parasites possibly release antigens previously hidden from the host's immune response.
为了确定盘尾丝虫病患者接受治疗后对盘尾丝虫抗原的抗体反应变化，在用乙胺嗪治疗前及治疗后的14天内，对21例患者和3名对照个体的IgG和IgE抗体进行了定量和定性检测。所有患者的IgE和IgG反应（多克隆和盘尾丝虫特异性）的定量水平基本保持不变，但21例患者中有9例对一种或多种寄生虫特异性抗原的反应增强，21例中有8例产生了针对先前未检测到的抗原的抗体。感染强度与新识别的抗盘尾丝虫抗体的产生之间存在显著相关性。这些研究表明，乙胺嗪治疗至少可短暂增强盘尾丝虫特异性IgE和IgG抗体反应，且治疗后，寄生虫可能释放了先前隐藏于宿主免疫反应的抗原。
