Department of Mathematics, University College London, London, United Kingdom.
J Acoust Soc Am. 2011 Oct;130(4):EL180-5. doi: 10.1121/1.3630219.
Interest in microbubble ultrasound contrast agents as therapeutic and quantitative imaging tools has increased the need for accurate modeling of their behavior. Experiments have shown that some bubbles shrink significantly over the course of a single pulse but that the bubbles may eventually reach a stable size after many insonations. Here, it is shown from dimensional arguments that diffusion phenomena are negligible on the time scales that characterize a typical ultrasound pulse. Subsequently, a new model describing both a lipid-shedding mechanism and a nonlinear surface viscosity is developed and shown to provide a more accurate description of the observed experimental behavior.
人们对微泡超声对比剂作为治疗和定量成像工具的兴趣日益增加，这就需要对其行为进行更准确的建模。实验表明，一些微泡在单个脉冲过程中会显著收缩，但经过多次超声辐照后，微泡最终可能会达到一个稳定的大小。本文从量纲分析的角度表明，在典型超声脉冲所表征的时间尺度上，扩散现象可以忽略不计。随后，开发了一种新的模型，该模型同时描述了脂滴脱落机制和非线性表面粘度，并表明该模型能够更准确地描述观察到的实验行为。
