Baba N
Department of Dermatology, Yokohama City University School of Medicine.
Nihon Hifuka Gakkai Zasshi. 1990 Feb;100(2):147-52.
59 specimens consisting of 10 psoriasis vulgaris, 1 squamous cell carcinoma, 1 Paget disease, 3 keratoacanthomas, 1 pemphigus vulgaris, 18 cutaneous T cell lymphomas, 2 ATLs, and other skin diseases were studied by immunoperoxidase technique. We used four antibodies to demonstrate a cell proliferation-associated antigen (PC, DNA polymerase-alpha and transferrin receptor) and epidermal growth factor receptor. Our observations suggested that the expression of PC and DNA polymerase-alpha may correlate well with cell proliferation, which were demonstrated in the epidermis of psoriasis vulgaris. Primary and metastatic squamous cell carcinoma and some of psoriasis vulgaris had a positive staining for EGF-R, while normal epidermis and almost all other skin diseases were negative.
采用免疫过氧化物酶技术对59份标本进行了研究，这些标本包括10例寻常型银屑病、1例鳞状细胞癌、1例佩吉特病、3例角化棘皮瘤、1例寻常型天疱疮、18例皮肤T细胞淋巴瘤、2例成人T细胞白血病以及其他一些皮肤疾病。我们使用了四种抗体来检测一种细胞增殖相关抗原（增殖细胞核抗原、DNA聚合酶α和转铁蛋白受体）以及表皮生长因子受体。我们的观察结果表明，增殖细胞核抗原和DNA聚合酶α的表达可能与细胞增殖密切相关，这在寻常型银屑病的表皮中得到了证实。原发性和转移性鳞状细胞癌以及部分寻常型银屑病的表皮生长因子受体染色呈阳性，而正常表皮以及几乎所有其他皮肤疾病均为阴性。
