JST-CREST, Chiyoda-ku, Tokyo, Japan.
Colloids Surf B Biointerfaces. 2012 Jan 1;89:223-7. doi: 10.1016/j.colsurfb.2011.09.020. Epub 2011 Sep 21.
A tri-block copolymer series containing hydrophilic polyrotaxane and hydrophobic poly(iso-butylmethacrylate) (PiBMA) segments was prepared by atom transfer radical polymerization (ATRP), starting from a pseudopolyrotaxane consisting of 2-bromoisobutyryl end-capped poly(ethylene glycol) (PEG) and α-cyclodextrin (α-CD) and followed by methylation. The dynamic wettability and molecular mobility of the copolymer surfaces were evaluated by dynamic contact angle (DCA) and quartz crystal microbalance with dissipation (QCM-D) measurements, respectively. The polyrotaxane tri-block copolymer surfaces were found to show pronounced dynamic wettability and molecular mobility compared to the control surfaces-a tri-block polymer consisting of PEG and PiBMA, and a PiBMA homopolymer-suggesting that a polyrotaxane loop-like structure exists at the outermost surface in an aqueous environment and exhibits dynamic properties attributable to the possible mobile nature of hydrated α-CD molecules along the PEG backbone. Finally, excellent protein adsorption repellency was achieved on the polyrotaxane tri-block copolymer surface, presumably due to the mobile nature of the supramolecular architecture on the surface.
一种包含亲水聚轮烷和疏水聚异丁基甲基丙烯酸酯（PiBMA）段的三嵌段共聚物通过原子转移自由基聚合（ATRP）制备，该共聚物以 2-溴异丁酰封端的聚（乙二醇）（PEG）和α-环糊精（α-CD）组成的拟聚轮烷为起始点，然后进行甲基化。通过动态接触角（DCA）和石英晶体微天平耗散（QCM-D）测量分别评估了共聚物表面的动态润湿性和分子迁移率。与对照表面（由 PEG 和 PiBMA 组成的三嵌段聚合物以及 PiBMA 均聚物）相比，聚轮烷三嵌段共聚物表面表现出明显的动态润湿性和分子迁移率，这表明在水环境中最外层存在聚轮烷环结构，并表现出动态特性归因于沿 PEG 主链的水合α-CD 分子的可能可移动性。最后，在聚轮烷三嵌段共聚物表面上实现了优异的蛋白质吸附排斥性，这可能归因于表面上超分子结构的可移动性。
