Rajendan Arun Kumar, Arisaka Yoshinori, Yui Nobuhiko, Iseki Sachiko
Section of Molecular Craniofacial Embryology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.
Department of Organic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo, 101-0062, Japan.
Inflamm Regen. 2020 Nov 11;40(1):27. doi: 10.1186/s41232-020-00136-5.
The field of tissue engineering and regeneration constantly explores the possibility of utilizing various biomaterials' properties to achieve effective and uneventful tissue repairs. Polyrotaxanes (PRXs) are supramolecular assemblies, which possess interesting mechanical property at a molecular scale termed as molecular mobility. This molecular mobility could be utilized to stimulate various cellular mechanosignaling elements, thereby altering the cellular functions. Apart from this, the versatile nature of PRXs such as the ability to form complex with growth factors and peptides, numerous sites for chemical modifications, and processability into different forms makes them interesting candidates for applications towards tissue engineering. This literature briefly reviews the concepts of PRXs and molecular mobility, the versatile nature of PRXs, and its emerging utility towards certain tissue engineering applications.
组织工程与再生领域一直在不断探索利用各种生物材料的特性来实现有效且顺利的组织修复的可能性。聚轮烷（PRXs）是超分子组装体，在分子尺度上具有一种有趣的机械性能，称为分子流动性。这种分子流动性可用于刺激各种细胞机械信号元件，从而改变细胞功能。除此之外，PRXs的多功能性质，如与生长因子和肽形成复合物的能力、众多的化学修饰位点以及可加工成不同形式，使其成为组织工程应用的有趣候选材料。本文献简要综述了PRXs和分子流动性的概念、PRXs的多功能性质及其在某些组织工程应用中的新兴用途。
