Park Hyung Dal, Lee Won Kyu, Ooya Tooru, Park Ki Dong, Kim Young Ha, Yui Nobuhiko
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi, Ishikawa 923-1292, Japan.
J Biomed Mater Res A. 2003 Sep 1;66(3):596-604. doi: 10.1002/jbm.a.10505.
Sulfonated polyrotaxanes (PRx-SO(3)'s), in which sulfonated alpha-cyclodextrins (alpha-CDs) were threaded onto the poly(ethylene glycol) (PEG) segments in a PEG-b-poly(propylene glycol) (PPG)-b-PEG triblock copolymer (Pluronic) capped with benzyloxycarbonyl (Z)-L-phenylalanine (Z-L-Phe), were prepared as a novel surface-modifying biomaterial. Surface modification of the polyurethane (PU) was carried out by blending the PRx-SO(3)'s with a PU solution, followed by solution casting. The incorporated PRx-SO(3)'s led to the enhanced hydrophilicity by changing the surface properties of the PU matrix. Modified PUs showed the stable entrapment of the PRx-SO(3)'s with little extraction into water and enhanced mechanical properties after exposure to water compared to the PU control. The incorporated PRx-SO(3)'s repelled the proteins and kept them from closely approaching the surface areas, prevented platelet activation by thrombin, and effectively repelled bacteria. These results suggest that both the supramolecular structure of the polyrotaxanes and exposure of the sulfonated groups onto the surfaces contribute to these phenomena. Thus, surface modification with PRx-SO(3)'s is suggested to be useful for the fabrication of biocompatible medical devices.
磺化聚轮烷（PRx-SO₃⁻）是一种新型的表面改性生物材料，它是将磺化的α-环糊精（α-CD）穿在聚（乙二醇）（PEG）链段上，该PEG链段位于用苄氧羰基（Z）-L-苯丙氨酸（Z-L-Phe）封端的聚（乙二醇）-b-聚（丙二醇）（PPG）-b-聚（乙二醇）三嵌段共聚物（普朗尼克）中。通过将PRx-SO₃⁻与聚氨酯（PU）溶液混合，然后溶液浇铸来对PU进行表面改性。掺入的PRx-SO₃⁻通过改变PU基质的表面性质导致亲水性增强。与PU对照相比，改性PU显示出PRx-SO₃⁻的稳定包埋，几乎没有萃取到水中，并且在暴露于水后机械性能增强。掺入的PRx-SO₃⁻排斥蛋白质并阻止它们紧密接近表面区域，防止凝血酶激活血小板，并有效地排斥细菌。这些结果表明，聚轮烷的超分子结构和磺化基团在表面的暴露都有助于这些现象。因此，用PRx-SO₃⁻进行表面改性被认为对制造生物相容性医疗设备是有用的。
