Department of Neurology, ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands.
J Neurol Sci. 2011 Dec 15;311(1-2):78-85. doi: 10.1016/j.jns.2011.09.008. Epub 2011 Oct 4.
Genetic factors partially explain the susceptibility of multiple sclerosis (MS) and might even relate to the clinical course. Still, many epidemiological studies point at an important role for environmental factors in MS. Smoking is one of the major candidates. In this review we provide an overview of the epidemiological studies on cigarette smoking and the association on MS risk and MS clinical course. In addition, we discuss the possible biological pathways that may influence neurological damage in MS. Moreover, the relation of smoking with other environmental MS risk factors will be addressed.
遗传因素部分解释了多发性硬化症（MS）的易感性，甚至可能与临床病程有关。尽管如此，许多流行病学研究表明环境因素在 MS 中起着重要作用。吸烟就是其中的主要候选因素之一。在这篇综述中，我们概述了关于吸烟与 MS 风险和 MS 临床病程关联的流行病学研究。此外，我们还讨论了可能影响 MS 神经损伤的生物学途径。此外，还将探讨吸烟与其他环境 MS 风险因素的关系。
