Hawkes C H
Essex Neuroscience Centre, Romford, Essex RM7 0BE, UK.
Mult Scler. 2007 Jun;13(5):610-5. doi: 10.1177/1352458506073501. Epub 2007 Feb 16.
Several case control studies have probed a link between cigarette smoking and subsequent multiple sclerosis (MS). Data collection and statistical methods have varied, and frequently, case numbers have been small. Publications relating to MS and smoking are reviewed and combined where comparable methods have been used. Metanalysis of six informative studies show significantly elevated odds or rate ratios, ranging from 1.22 to 1.51, depending on the method of analysis, confirming that the risk of MS is increased for those who smoke prior to disease onset, as measured by commencement of symptoms. A variety of direct causative mechanisms are discussed, but an indirect association through health adverse conduct is favoured.
几项病例对照研究探讨了吸烟与随后发生的多发性硬化症（MS）之间的联系。数据收集和统计方法各不相同，而且病例数往往较少。对与MS和吸烟相关的出版物进行了综述，并将使用了可比方法的研究进行了合并。对六项信息性研究的荟萃分析表明，根据分析方法的不同，优势比或率比显著升高，范围在1.22至1.51之间，这证实了在疾病症状开始时测量，那些在疾病发作前吸烟的人患MS的风险会增加。文中讨论了多种直接的致病机制，但更倾向于通过有害健康行为产生的间接关联。
