Ruíz-Hernández Nelina, Espinoza-Zavala Milagros, González Julio C, Leal-Herrera Ulises, Reigosa-Yaniz Aldo
Instituto de Investigaciones en Nutrición (INVESNUT), Facultad de Ciencias de la Salud. Universidad de Carabobo (UC) Departamento de Morfofisiopatología, Escuela de Bioanálisis. Universidad de Carabobo (UC).
Arch Cardiol Mex. 2011 Jul-Sep;81(3):188-96.
To establish whether increased serum uric acid is associated with higher levels of oxidized LDL (oxLDL), antibodies against human oxidized LDL (oxLDL Ab) and ratios of LDL oxidation in overweight women.
Cross-sectional study that included 114 women with body mass index ? 25 kg/m2. We determined weight, height, waist circumference, blood pressure, glycemia, uric acid, lipid profile, creatinine, Apolipoprotein B (ApoB), oxLDL, oxLDL Ab, insulin and insulin resistance was estimated using HOMA. Body mass index, LDL-associated ApoB, rates of LDL oxidation and tertiles of uric acid were calculated. Metabolic syndrome was defined using NCEP/ATP III criteria.
Of the women studied 51.8% were overweight and the rest was classified as obese; 66.7% had metabolic syndrome. In the total group and overweight group, only the oxLDL/HDL cholesterol ratio was significantly higher in the last tertile of uric acid. The serum levels of circulanting oxLDL and oxLDL/cholesterol, oxLDL/HDL cholesterol, oxLDL/ApoB and oxLDL/ LDL-associated ApoB ratios were significantly higher among obese women located in the highest tertile of uric acid. Concentrations of oxLDL Ab and oxLDL/oxLDL Ab were not related to the uric acid. Serum uric acid and ApoB predicted the elevation of oxLDL.
Increased serum uric acid was associated with more oxidation of LDL among obese women. This suggests the importance of regular monitoring of uric acid in overweight women. Prospective research should be conducted.
确定超重女性血清尿酸升高是否与氧化型低密度脂蛋白（oxLDL）水平升高、抗人氧化型低密度脂蛋白抗体（oxLDL Ab）以及低密度脂蛋白氧化率相关。
横断面研究纳入了114名体重指数≥25 kg/m²的女性。我们测定了体重、身高、腰围、血压、血糖、尿酸、血脂谱、肌酐、载脂蛋白B（ApoB）、oxLDL、oxLDL Ab，并使用稳态模型评估法（HOMA）估算胰岛素和胰岛素抵抗。计算体重指数、与低密度脂蛋白相关的ApoB、低密度脂蛋白氧化率和尿酸三分位数。采用美国国家胆固醇教育计划成人治疗组第三次报告（NCEP/ATP III）标准定义代谢综合征。
在所研究的女性中，51.8%为超重，其余被归类为肥胖；66.7%患有代谢综合征。在整个研究组和超重组中，仅尿酸最高三分位数组的oxLDL/高密度脂蛋白胆固醇比值显著更高。在尿酸最高三分位数的肥胖女性中，循环oxLDL的血清水平以及oxLDL/胆固醇、oxLDL/高密度脂蛋白胆固醇、oxLDL/ApoB和oxLDL/与低密度脂蛋白相关的ApoB比值显著更高。oxLDL Ab浓度和oxLDL/oxLDL Ab与尿酸无关。血清尿酸和ApoB可预测oxLDL升高。
肥胖女性血清尿酸升高与更多的低密度脂蛋白氧化相关。这表明对超重女性定期监测尿酸的重要性。应开展前瞻性研究。
