Ruiz-Fernández Nelina, Bosch Virgilio, Giacopini Maria Isabel
Departamento de Morfofisiopatología, Escuela de Bioanálisis de la Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Carabobo, Venezuela. ; Instituto de Investigaciones en Nutrición (INVESNUT), Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Carabobo, Venezuela.
Sección de Lipidología del Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.
Colomb Med (Cali). 2016 Dec 30;47(4):181-188.
To establish association between socioeconomic status and plasmatic markers of lipoperoxidation and antioxidants in Venezuelan school-age children from the middle-class and in critical poverty.
Cross-sectional study with a sample of 114 school-age children (aged 7-9). The socioeconomic status, dietary intake of macro and micro-nutrients, weight, height, lipid profile, indicators of lipid peroxidation and enzymatic and non-enzymatic antioxidants were determined.
The daily average intake of energy, carbohydrates and vitamin A, and the percentage of energy obtained from carbohydrates was significantly higher in middle-class children compared to critical poverty children ( <0.05). The circulating oxidized low density lipoprotein ( <0.001) and the susceptibility of low density lipoproteins and very low density lipoproteins to oxidation ( <0.05) were significantly higher in middle-class children, while the critical poverty children showed significantly lower levels of Vitamin C and E in plasma ( <0.05). Non-enzymatic antioxidant levels were frequently deficient in both strata. The concentrations of circulating oxidized low density lipoprotein (OR: 1.09, CI : 1.016-1.179; = 0.017) and Vitamin C (OR: 3.21, CI : 1.104-9.938; = 0.032) were associated to the socioeconomic status independently of gender, family history of premature coronary artery disease, triglicerides, Vitamin C and E dietary intake and count of white blood cells.
The socioeconomic status was associated to circulating oxidized low density lipoprotein and Vitamin C in Venezuelan school-age children, The results suggested the need to improve the dietary intake of antioxidants in both studied socioeconomic groups.
确定委内瑞拉中产阶级和处于极度贫困状态的学龄儿童的社会经济地位与脂质过氧化和抗氧化剂血浆标志物之间的关联。
对114名学龄儿童（7至9岁）进行横断面研究。测定了社会经济地位、常量和微量营养素的饮食摄入量、体重、身高、血脂谱、脂质过氧化指标以及酶促和非酶促抗氧化剂。
与处于极度贫困状态的儿童相比，中产阶级儿童的每日平均能量、碳水化合物和维生素A摄入量以及碳水化合物提供的能量百分比显著更高（<0.05）。中产阶级儿童的循环氧化低密度脂蛋白水平（<0.001）以及低密度脂蛋白和极低密度脂蛋白的氧化易感性（<0.05）显著更高，而处于极度贫困状态的儿童血浆中维生素C和E水平显著更低（<0.05）。两个阶层的非酶促抗氧化剂水平经常不足。循环氧化低密度脂蛋白浓度（OR：1.09，CI：1.016 - 1.179；= 0.017）和维生素C浓度（OR：3.21，CI：1.104 - 9.938；= 0.032）与社会经济地位相关，且独立于性别、早发冠状动脉疾病家族史、甘油三酯、维生素C和E的饮食摄入量以及白细胞计数。
在委内瑞拉学龄儿童中，社会经济地位与循环氧化低密度脂蛋白和维生素C相关。结果表明，在所研究的两个社会经济群体中都需要改善抗氧化剂饮食摄入量。
