Lega Bradley C, Kahana Michael J, Jaggi Jurg, Baltuch Gordon H, Zaghloul Kareem
Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuroreport. 2011 Nov 16;22(16):795-800. doi: 10.1097/WNR.0b013e32834b2975.
Accumulated evidence from animal studies implicates the ventral striatum in the processing of reward information. Recently, deep brain stimulation (DBS) surgery has enabled researchers to analyze neurophysiological recordings from humans engaged in reward tasks. We present data recorded from the human ventral striatum during deep brain stimulation surgery as a participant played a video game coupled to the receipt of visual reward images. To our knowledge, we identify the first instances of reward-sensitive single unit activity in the human ventral striatum. Local field potential data suggest that alpha oscillations are sensitive to positive feedback, whereas beta oscillations exhibit significantly higher power during unrewarded trials. We report evidence of alpha-gamma cross-frequency coupling that differentiates between positive and negative feedback.
动物研究积累的证据表明腹侧纹状体参与奖励信息的处理。最近，深部脑刺激（DBS）手术使研究人员能够分析参与奖励任务的人类的神经生理学记录。我们展示了在深部脑刺激手术期间，一名参与者玩与接收视觉奖励图像相关的视频游戏时从人类腹侧纹状体记录的数据。据我们所知，我们识别出了人类腹侧纹状体中奖励敏感单单位活动的首个实例。局部场电位数据表明，α振荡对正反馈敏感，而β振荡在无奖励试验期间表现出显著更高的功率。我们报告了区分正反馈和负反馈的α-γ交叉频率耦合的证据。
