Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
Chem Commun (Camb). 2011 Nov 21;47(43):11930-2. doi: 10.1039/c1cc14957a. Epub 2011 Oct 5.
Strand proximity and self-crossing that occur intrinsically in the relaxed forms of toroidal DNA are utilized unprecedentedly in our investigations for creating catenated DNA rings. In addition, our current studies show that the geometrical shapes of our newly obtained catenated DNA circles as well as their topological arrangements are vividly visible under atomic force microscopic examination.
在我们研究中环型 DNA 交联的过程中，前所未用地利用了其松弛形式中固有的链亲和和自身交叉。此外，我们目前的研究表明，在原子力显微镜检查下，我们新获得的交联 DNA 环的几何形状及其拓扑排列清晰可见。
