Department of Pharmacology, Kaohsiung Medical University, Taiwan.
J Water Health. 2011 Sep;9(3):498-506. doi: 10.2166/wh.2011.006.
The objective of this study was to explore whether calcium (Ca) levels in drinking water modified the effects of nitrate on colon cancer risk. A matched case-control study was used to investigate the relationship between the risk of death from colon cancer and exposure to nitrate in drinking water in Taiwan. All colon cancer deaths of Taiwan residents from 2003 through 2007 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth and year of death. Information on the levels of nitrate-nitrogen (NO(3)-N) and Ca in drinking water have been collected from Taiwan Water Supply Corporation (TWSC). The municipality of residence for cases and controls was assumed to be the source of the subject's NO(3)-N and Ca exposure via drinking water. We observed evidence of an interaction between drinking water NO(3)-N and Ca intake via drinking water. This is the first study to report effect modification by Ca intake from drinking water on the association between NO(3)-N exposure and risk of colon cancer mortality.
本研究旨在探讨饮用水中的钙 (Ca) 水平是否会改变硝酸盐对结肠癌风险的影响。采用匹配病例对照研究，调查了台湾地区饮用水中硝酸盐暴露与结肠癌死亡风险之间的关系。所有 2003 年至 2007 年台湾居民死于结肠癌的病例均来自台湾省卫生署生命统计处。对照组为其他原因导致的死亡，并通过性别、出生年份和死亡年份与病例进行配对。饮用水中硝酸盐氮（NO3-N）和 Ca 的水平信息来自台湾自来水公司（TWSC）。根据病例和对照的居住地，假设饮用水是通过饮用水摄入硝酸盐氮（NO3-N）和 Ca 的来源。我们观察到饮用水 NO3-N 和 Ca 摄入之间存在交互作用的证据。这是第一项报告饮用水中 Ca 摄入对 NO3-N 暴露与结肠癌死亡率之间关联的修饰作用的研究。
