疟原虫隐匿于一位弥漫性大 B 细胞淋巴瘤合并镰状细胞特征的患者体内。
Malaria hidden in a patient with diffuse large-B-cell lymphoma and sickle-cell trait.
机构信息
Department of Biochemistry and Molecular Biology IV and Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Ciudad Universitaria, 28040 Madrid, Spain.
出版信息
J Clin Microbiol. 2011 Dec;49(12):4401-4. doi: 10.1128/JCM.00911-11. Epub 2011 Oct 5.
Abstract
We report a case of an African patient with sickle cell trait who was diagnosed in Spain with B-cell lymphoma. Blood smears were negative for malaria, and no plasmodium antigens were detected in the blood. To treat his lymphoma, the patient underwent chemotherapy and autologous stem cell transplantation. Following a splenectomy due to a worsening condition, he developed clinical malaria with detectable parasitemia. This case suggests that the humoral response and parasite removal by the spleen may afford protection from overt disease and may even help maintain subclinical human reservoirs of the disease.
摘要
我们报告了一例患有镰状细胞特征的非洲患者，该患者在西班牙被诊断出患有 B 细胞淋巴瘤。血涂片阴性排除疟疾，血液中也未检测到疟原虫抗原。为了治疗淋巴瘤，该患者接受了化疗和自体干细胞移植。由于病情恶化，行脾切除术，随后出现有可检测到寄生虫血症的临床疟疾。该病例表明，脾脏的体液反应和寄生虫清除可能提供对显性疾病的保护，甚至有助于维持疾病的亚临床人类储主。
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