Singh Amrit Pal, Goel Rajesh Kumar, Kaur Tajpreet
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar - 143 005.
Toxicol Int. 2011 Jul;18(2):87-93. doi: 10.4103/0971-6580.84258.
Arsenic is an environmental pollutant and its contamination in the drinking water is considered as a serious worldwide environmental health threat. The chronic arsenic exposure is a cause of immense health distress as it accounts for the increased risk of various disorders such as cardiovascular abnormalities, diabetes mellitus, neurotoxicity, and nephrotoxicity. In addition, the exposure to arsenic has been suggested to affect the liver function and to induce hepatotoxicity. Moreover, few studies demonstrated the induction of carcinogenicity especially cancer of the skin, bladder, and lungs after the chronic exposure to arsenic. The present review addresses diverse mechanisms involved in the pathogenesis of arsenic-induced toxicity and end-organ damage.
砷是一种环境污染物，其在饮用水中的污染被认为是全球范围内严重的环境卫生威胁。长期接触砷会导致巨大的健康困扰，因为它会增加患各种疾病的风险，如心血管异常、糖尿病、神经毒性和肾毒性。此外，已有研究表明接触砷会影响肝功能并诱发肝毒性。此外，少数研究表明，长期接触砷后会诱发致癌性，尤其是皮肤癌、膀胱癌和肺癌。本综述阐述了砷诱导毒性和终末器官损伤发病机制中涉及的多种机制。
