Saxena Prabhu N, Anand Shalini, Saxena Nishi, Bajaj Priya
Toxicology Laboratory, School of Life Sciences, Department of Zoology, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India.
J Environ Biol. 2009 Jul;30(4):527-31.
The protective effects of Curcuma aromatica leaf extract were studied on nehrotoxicity induced by arsenic trioxide in albino rats. LD50 estimated for arsenic trioxide was 14.98 mg kg(-1) body weight. Nephrotoxicity was assessed by estimating the serum levels of urea, uric acid and creatinine, the markers of renal dysfunctioning. The applied doses of arsenic trioxide administered orally were 0.007, 0.01, 0.02 and 0.15 mg 100 g(-1) body weight for sub acute (21,14 and 7 days) and acute (1 day) treatments respectively. Arsenic trioxide intoxication significantly increased the serum level of urea, uric acid and creatinine in comparison to control due to renal dysfunctioning. Pretreatment with dose of 50 mg kg(-1) body weight of leaf extract of Curcuma aromatica restored the increased serum levels of urea, uric acid and creatinine to normal. The results reveal that Curcuma aromatica leaf extract has a potential to modulate the renal dysfunctioning caused by arsenic trioxide.
研究了莪术叶提取物对白化病大鼠三氧化二砷诱导的肾毒性的保护作用。三氧化二砷的半数致死量估计为14.98毫克/千克体重。通过评估血清尿素、尿酸和肌酐水平（肾功能障碍的标志物）来评估肾毒性。口服给予三氧化二砷的应用剂量分别为0.007、0.01、0.02和0.15毫克/100克体重，用于亚急性（21、14和7天）和急性（1天）治疗。由于肾功能障碍，与对照组相比，三氧化二砷中毒显著提高了血清尿素、尿酸和肌酐水平。用50毫克/千克体重的莪术叶提取物预处理可使升高的血清尿素、尿酸和肌酐水平恢复正常。结果表明，莪术叶提取物具有调节三氧化二砷引起的肾功能障碍的潜力。
