Ahmad Reyaz, Chana Rajendra Singh, Ali Syed Manazir, Khan Shehtaj
Department of Pediatric Surgery, Sawai Man Singh Medical College, Jaipur, India.
Urol Ann. 2011 Sep;3(3):138-40. doi: 10.4103/0974-7796.84966.
To evaluate the effect of parenteral testosterone on penile length, preputial skin and side effects in patients with hypospadias.
23 patients with hypospadias were included in this study. An oily solution, each ml of which contained testosterone propionate 25 mg, and testosterone enanthate 110 mg, equivalent to 100 mg of testosterone was given deep intramuscularly 4, 3 and 2 weeks before reconstructive surgery at the dose of 2 mg/kg body weight. Increase in penile length, transverse preputial diameter, and diameter at the base of penis were noted. Basal testosterone levels were obtained before the institution of therapy and on the day of operation. In addition, side effect such as development of pubic hair and delay in bone age was noted.
Following parenteral testosterone administration, the mean increase in penile length, transverse preputial diameter and diameter at the base of penis was 1.35±0.40 cm (P<0.001), 1.40±0.47 cm (P<0.001), and 0.72±0.47 cm (P<0.001), respectively. Serum testosterone level after injection was well within normal range for that age. Minimal side effects were noted in form of development of fine pubic hair.
We conclude that parenteral testosterone can be safely used to improve the surgical outcome of hypospadias repair.
评估肠外给予睾酮对尿道下裂患者阴茎长度、包皮皮肤及副作用的影响。
本研究纳入23例尿道下裂患者。在重建手术前4周、3周和2周，以2mg/kg体重的剂量将一种油溶液深部肌内注射，该溶液每毫升含丙酸睾酮25mg和庚酸睾酮110mg，相当于100mg睾酮。记录阴茎长度、包皮横向直径和阴茎基部直径的增加情况。在治疗开始前和手术当天测定基础睾酮水平。此外，记录诸如阴毛生长和骨龄延迟等副作用。
肠外给予睾酮后，阴茎长度、包皮横向直径和阴茎基部直径的平均增加分别为1.35±0.40cm（P<0.001）、1.40±0.47cm（P<0.001）和0.72±0.47cm（P<0.001）。注射后血清睾酮水平在该年龄的正常范围内。观察到以细小阴毛生长形式出现的最小副作用。
我们得出结论，肠外给予睾酮可安全用于改善尿道下裂修复的手术效果。
