Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Diabetes Metab J. 2011 Aug;35(4):390-6. doi: 10.4093/dmj.2011.35.4.390. Epub 2011 Aug 31.
Diabetes mellitus is a major independent risk factor for cardiovascular disease (CVD), but high cardiovascular risk in diabetes mellitus patients is not completely explained by clustering traditional risk factors. Recently, associations between diabetic polyneuropathy (DPN) and macrovasculopathy have been suggested. We aimed to assess associations between DPN and cardiovascular complications in type 2 diabetic patients.
Microvascular and cardiovascular complications were evaluated in 1,041 type 2 diabetic patients.
In patients with DPN, the age, prevalence of hypertension, diabetes duration, systolic blood pressure, pulse pressure, and hemoglobin glycation (HbA1c) levels were significantly higher, while the high density lipoprotein cholesterol (HDL-C) levels were lower than in those without DPN. The prevalence of CVD was higher in patients with DPN. In multivariate analysis, DPN was independently associated with CVD (odds ratio, 1.801; 95% confidence interval, 1.009 to 3.214).
Our results showed that DPN was associated with a high prevalence of cardiovascular disease in type 2 diabetic patients, but further studies are needed to investigate the causative nature of associations between DPN and CVD.
糖尿病是心血管疾病（CVD）的一个主要独立危险因素，但糖尿病患者的高心血管风险不能完全用传统危险因素的聚集来解释。最近，有人提出糖尿病多发性神经病变（DPN）与大血管病变之间存在关联。我们旨在评估 2 型糖尿病患者中 DPN 与心血管并发症之间的关系。
对 1041 例 2 型糖尿病患者进行了微血管和心血管并发症的评估。
在 DPN 患者中，年龄、高血压患病率、糖尿病病程、收缩压、脉压和血红蛋白糖化（HbA1c）水平显著升高，而高密度脂蛋白胆固醇（HDL-C）水平则较低。DPN 患者的 CVD 患病率更高。在多变量分析中，DPN 与 CVD 独立相关（比值比，1.801；95%置信区间，1.009 至 3.214）。
我们的结果表明，DPN 与 2 型糖尿病患者心血管疾病的高患病率相关，但需要进一步的研究来探讨 DPN 与 CVD 之间关联的因果性质。
