Zhang T
Institute of Northern Engineering, University of Alaska, Fairbanks 306 Tanana Drive, Duckering Building, Fairbanks, AK 99775-5910, USA.
Mol Cell Biomech. 2011 Sep;8(3):169-93.
Cytoplasmic motion assumed as a steady state laminar flow induced by cytoskeleton stretching in a cell is determined and its effect on the mechanical behavior of the cell under externally applied forces is demonstrated. Non-Newtonian fluid is assumed for the multiphase cytoplasmic fluid and the analytical velocity field around the macromolecular chain is obtained by solving the reduced nonlinear momentum equation using homotopy technique. The entropy generation by the fluid internal friction is calculated and incorporated into the entropic elasticity based 8-chain constitutive relations. Numerical examples showed strengthening behavior of cells in response to externally applied mechanical stimuli. The spatial distribution of the stresses within a cell under externally applied fluid flow forces were also studied.
确定了细胞中由细胞骨架拉伸诱导的细胞质运动为稳态层流，并展示了其在外部施加力作用下对细胞力学行为的影响。假设多相细胞质流体为非牛顿流体，并通过使用同伦技术求解简化的非线性动量方程，得到了大分子链周围的解析速度场。计算了流体内部摩擦产生的熵，并将其纳入基于熵弹性的8链本构关系中。数值例子表明细胞在外部施加的机械刺激下表现出强化行为。还研究了在外部施加的流体流动作用力下细胞内应力的空间分布。
