The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
J Altern Complement Med. 2011 Oct;17(10):909-13. doi: 10.1089/acm.2011.0205. Epub 2011 Oct 6.
Sepsis results in significant morbidity and mortality, with current treatment options limited with respect to efficacy as well as safety. The complex homeopathic remedy Traumeel S has been shown to have both anti-inflammatory and immunostimulatory effects in the in vitro setting.
The objective was to explore the effects of Traumeel S in an in vivo setting, using a cecal ligation and puncture (CLP) sepsis model in rats, evaluating the effects of the medication on cytokine activity.
Sepsis was induced in 30 rats using accepted CLP methodology. Following the procedure, rats were randomly allocated to receive an intraperitoneal injection of either Traumeel S (n=15) or normal saline (n=15). At 6 hours post-CLP, serum cytokines (interleukin [IL]-1β, tumor necrosis factor-α, IL-6, and IL-10) were evaluated.
IL-1β levels were significantly higher in the treatment group (p=0.03) with no significant differences found between the groups with respect to the other cytokines tested.
In contrast to in vitro studies, Traumeel significantly increased IL-1β levels in an in vivo model, without influencing other cytokines. IL-1β is a proinflammatory cytokine that has been shown to have a protective effect in the CLP rat model. Further research is warranted to examine this finding, as well as its clinical implications.
脓毒症会导致严重的发病率和死亡率，目前的治疗选择在疗效和安全性方面都受到限制。复杂的顺势疗法药物 Traumeel S 已被证明在体外具有抗炎和免疫刺激作用。
本研究旨在探讨 Traumeel S 在体内环境中的作用，使用盲肠结扎和穿刺（CLP）脓毒症大鼠模型，评估该药物对细胞因子活性的影响。
采用公认的 CLP 方法在 30 只大鼠中诱导脓毒症。手术后，大鼠随机分为接受 Traumeel S（n=15）或生理盐水（n=15）腹腔注射的两组。在 CLP 后 6 小时，评估血清细胞因子（白细胞介素[IL]-1β、肿瘤坏死因子-α、IL-6 和 IL-10）。
治疗组的 IL-1β 水平显著升高（p=0.03），而两组间其他测试的细胞因子无显著差异。
与体外研究相反，Traumeel S 在体内模型中显著增加了 IL-1β 水平，而不影响其他细胞因子。IL-1β 是一种促炎细胞因子，在 CLP 大鼠模型中已被证明具有保护作用。需要进一步研究以检验这一发现及其临床意义。
