Laboratory of Stem Cell and Neuro-Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10/6C103, 10 Center Drive, Bethesda, MD 20892, United States.
Semin Cell Dev Biol. 2011 Dec;22(9):1019-27. doi: 10.1016/j.semcdb.2011.09.010. Epub 2011 Sep 29.
The nervous system relies on a highly specialized network of blood vessels for development and neuronal survival. Recent evidence suggests that both the central and peripheral nervous systems (CNS and PNS) employ multiple mechanisms to shape the vascular tree to meet its specific metabolic demands, such as promoting nerve-artery alignment in the PNS or the development the blood brain barrier in the CNS. In this article we discuss how the nervous system directly influences blood vessel patterning resulting in neuro-vascular congruence that is maintained throughout development and in the adult.
神经系统依赖高度专业化的血管网络来发育和维持神经元存活。最近的证据表明，中枢神经系统 (CNS) 和周围神经系统 (PNS) 都采用多种机制来塑造血管树以满足其特定的代谢需求，例如促进 PNS 中的神经-动脉对齐或 CNS 中血脑屏障的发育。在本文中，我们讨论了神经系统如何直接影响血管模式形成，从而导致神经血管一致性，这种一致性在发育过程中和成年期都能得到维持。
