Suega Ketut, Bakta I Made
Department of Internal Medicine, Faculty of Medicine, Udayana University-Sanglah Hospital, Denpasar Bali, Indonesia.
Acta Med Indones. 2011 Jul;43(3):162-7.
to examine the relationship between clinical stage of solid cancers and plasma D dimer value.
patients with solid cancer treated in Sanglah hospital who met study ctiteria were consecutively recruited and studied in order to examine the relationship between clinical stage of solid cancers and plasma D dimer value. Plasma D dimer was measured by ELISA (Nycocard) and TNM system to assign each patient into stage I,II,III and IV according to American Joint Committee on Cancer. Rank Spearman analysis was used to determine the relationship and one way Anova to compare the mean difference of D dimer between group of clinical stages.
there were 79 patients included, mostly female (72,2%) and 57% was in age group of 40-59 years old. Level of D dimer >500 ng/ml were found in 60 patients and 19 patients with D dimer <500 ng/ml. The most frequent cancer was cervix (32.9%) then followed by nasopharyng cancer (16.5%). Clinical stage I,II,III, and IV were 6.3%, 16.5%, 53.2% and 24.1% respectively. Thrombocytosis (>400.103/uL) was found 50.6% as well as leukocytosis 62%. Although the differences of mean D dimer in each type of solid cancers were big enough but it was not statistically significant (p = 0.156). Plasma D dimer was positively correlated with clinical stage of solid cancers (r = 0.367; p = 0.001).
plasma D dimer level was positively correlated with clinical stage of solid cancers. High plasma D dimer could be a marker for advanced stage of a patient with solid cancer.
探讨实体癌临床分期与血浆D-二聚体值之间的关系。
连续招募在桑格拉医院接受治疗且符合研究标准的实体癌患者，以研究实体癌临床分期与血浆D-二聚体值之间的关系。采用酶联免疫吸附测定法（Nycocard）检测血浆D-二聚体，并根据美国癌症联合委员会的TNM系统将每位患者分为I、II、III和IV期。采用Spearman秩分析确定两者之间的关系，并采用单因素方差分析比较各临床分期组间D-二聚体的平均差异。
共纳入79例患者，其中大多数为女性（72.2%），57%的患者年龄在40 - 59岁之间。60例患者的D-二聚体水平>500 ng/ml，19例患者的D-二聚体<500 ng/ml。最常见的癌症是宫颈癌（32.9%），其次是鼻咽癌（16.5%）。临床I期、II期、III期和IV期分别为6.3%、16.5%、53.2%和24.1%。50.6%的患者出现血小板增多（>400×10³/μL），62%的患者出现白细胞增多。虽然每种实体癌的平均D-二聚体差异足够大，但差异无统计学意义（p = 0.156）。血浆D-二聚体与实体癌临床分期呈正相关（r = 0.367；p = 0.001）。
血浆D-二聚体水平与实体癌临床分期呈正相关。高血浆D-二聚体可能是实体癌患者晚期的一个标志物。
