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激光治疗慢性牙周炎的效果与龈上洁治术一样好吗?

Are lasers as effective as scaling for chronic periodontitis?

作者信息

Niederman Richard

机构信息

Centre for Evidence-Based Dentistry, The Forsyth Institute, Boston, Massachusetts, USA.

出版信息

Evid Based Dent. 2011;12(3):80-1. doi: 10.1038/sj.ebd.6400811.

Abstract

DATA SOURCES

Medline, Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts of Reviews of Effects (DARE), CINAHL, Science Direct, ISI Web of Science, and SCOPUS. The following journals were hand searched: Journal of Periodontology, International Journal of Periodontics and Restorative Dentistry, Journal of Clinical Periodontology, Journal of Dental Research, Journal of Periodontal Research, Periodontology 2000, Journal of Dentistry, Journal of American Dental Associations, Journal of Clinical Dentistry, Lasers in Medical Science, Lasers in Surgery and Medicine, Clinical Oral Investigations, and Photomedicine and Laser Surgery as well as the reference lists of included articles.

STUDY SELECTION

Randomised controlled clinical trials (RCTs) comparing Er:YAG laser with manual or ultrasonic SRP alone were included. No language restrictions were applied.

DATA EXTRACTION AND SYNTHESIS

Data were collected by two independent reviewers with only numeric data being extracted. Data were combined for meta-analysis with the effect size being estimated and reported as the mean difference (MD) for continuous variables using a random effects model. Heterogeneity was assessed using the ÷2-based Q-statistic method and I(2) measurement.

RESULTS

Five trials met the inclusion criteria. Five trials (85 patients and 3,564 sites) were entered in the meta-analysis to investigate clinical attachment level (CAL) gain, pocket depth (PD) reduction and gingival recession (GR). All studies reported significant intragroup improvement in clinical and microbiological parameters in patients treated with the Er:YAG laser. However, three studies did not report a significant difference between Er:YAG laser and SRP groups in CAL gain, PD reduction or GR changes. The meta-analysis revealed no significant differences for any investigated parameters at six and 12 months.

CONCLUSIONS

Significant heterogeneity, a high risk of bias in three of the five included studies, and methodological shortcomings indicate that the results should be considered with caution. Future long-term, well-designed RCTs are needed to assess the scientific evidence of Er:YAG laser efficacy as an alternative treatment strategy to SRP.

摘要

数据来源

医学文献数据库(Medline)、考克兰系统评价数据库(CDSR)、循证医学数据库(DARE)、护理学与健康领域数据库(CINAHL)、科学Direct数据库、科学引文索引(ISI Web of Science)以及Scopus数据库。对手检了以下期刊:《牙周病学杂志》《国际牙周病与修复牙科杂志》《临床牙周病学杂志》《牙科研究杂志》《牙周病研究杂志》《牙周病学2000》《牙科杂志》《美国牙科协会杂志》《临床牙科杂志》《医学激光杂志》《激光手术与医学杂志》《临床口腔研究》《光医学与激光手术》以及纳入文章的参考文献列表。

研究选择

纳入比较铒激光与单独手动或超声龈下刮治术(SRP)的随机对照临床试验(RCT)。不设语言限制。

数据提取与综合分析

由两名独立评审员收集数据,仅提取数值数据。将数据合并进行荟萃分析,使用随机效应模型估计效应大小并将连续变量的效应大小报告为平均差(MD)。使用基于卡方的Q统计方法和I²测量评估异质性。

结果

五项试验符合纳入标准。五项试验(85名患者和3564个位点)纳入荟萃分析,以研究临床附着水平(CAL)增加、牙周袋深度(PD)减少和牙龈退缩(GR)情况。所有研究均报告,接受铒激光治疗的患者在临床和微生物学参数方面组内有显著改善。然而,三项研究未报告铒激光组与SRP组在CAL增加、PD减少或GR变化方面存在显著差异。荟萃分析显示,在6个月和12个月时,任何研究参数均无显著差异。

结论

显著的异质性、五项纳入研究中有三项存在高偏倚风险以及方法学缺陷表明,应谨慎看待这些结果。需要未来进行长期、设计良好的RCT来评估铒激光作为SRP替代治疗策略疗效的科学证据。

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