• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis.

作者信息

Lolis E, Petsko G A

机构信息

Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139.

出版信息

Annu Rev Biochem. 1990;59:597-630. doi: 10.1146/annurev.bi.59.070190.003121.

DOI:10.1146/annurev.bi.59.070190.003121
PMID:2197984
Abstract
摘要

相似文献

1
Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis.蛋白质晶体学中的过渡态类似物：酶催化结构来源的探针
Annu Rev Biochem. 1990;59:597-630. doi: 10.1146/annurev.bi.59.070190.003121.
2
Chemical studies of enzyme active sites.酶活性位点的化学研究。
Annu Rev Biochem. 1975;44:899-931. doi: 10.1146/annurev.bi.44.070175.004325.
3
The transition between the open and closed states of rubisco is triggered by the inter-phosphate distance of the bound bisphosphate.核酮糖-1,5-二磷酸羧化酶/加氧酶（Rubisco）开放态与关闭态之间的转变由结合的双磷酸酯的磷酸间距离触发。
J Mol Biol. 2000 May 19;298(5):903-16. doi: 10.1006/jmbi.2000.3724.
4
Enzyme catalysis: not different, just better.酶催化：并非不同，只是更好。
Nature. 1991 Mar 14;350(6314):121-4. doi: 10.1038/350121a0.
5
Multiple conformational changes in enzyme catalysis.酶催化中的多种构象变化。
Biochemistry. 2002 Jul 2;41(26):8221-8. doi: 10.1021/bi0260839.
6
Structural analysis of altered large-subunit loop-6/carboxy-terminus interactions that influence catalytic efficiency and CO2/O2 specificity of ribulose-1,5-bisphosphate carboxylase/oxygenase.对影响1,5-二磷酸核酮糖羧化酶/加氧酶催化效率和CO2/O2特异性的大亚基环6/羧基末端相互作用改变的结构分析。
Biochemistry. 2007 Oct 2;46(39):11080-9. doi: 10.1021/bi701063f. Epub 2007 Sep 8.
7
The development of enzyme catalytic efficiency: an experimental approach.酶催化效率的发展：一种实验方法。
Cold Spring Harb Symp Quant Biol. 1987;52:597-602. doi: 10.1101/sqb.1987.052.01.068.
8
To build an enzyme...
Philos Trans R Soc Lond B Biol Sci. 1991 May 29;332(1263):115-21. doi: 10.1098/rstb.1991.0039.
9
Whither enzyme mechanisms?酶机制何去何从？
FEBS Lett. 1976 Feb 4;62(SUPPL):E53-61. doi: 10.1016/0014-5793(76)80854-x.
10
Altered intersubunit interactions in crystal structures of catalytically compromised ribulose-1,5-bisphosphate carboxylase/oxygenase.催化受损的1,5-二磷酸核酮糖羧化酶/加氧酶晶体结构中亚基间相互作用的改变
Biochemistry. 2005 Jan 11;44(1):113-20. doi: 10.1021/bi047928e.

引用本文的文献

1
Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions.结合肽膦酸盐的结构揭示了诺卡菌素双功能硫酯酶外消旋酶-水解酶半反应的机制。
Nat Commun. 2019 Aug 27;10(1):3868. doi: 10.1038/s41467-019-11740-6.
2
Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism.牛胰核糖核酸酶：首个酶促反应机制的五十年。
Biochemistry. 2011 Sep 20;50(37):7835-41. doi: 10.1021/bi201075b. Epub 2011 Aug 24.
3
High resolution crystal structures of triosephosphate isomerase complexed with its suicide inhibitors: the conformational flexibility of the catalytic glutamate in its closed, liganded active site.
三磷酸甘油醛异构酶与其自杀抑制剂复合物的高分辨率晶体结构：催化谷氨酸在其封闭的配体活性位点中的构象灵活性。
Protein Sci. 2011 Aug;20(8):1387-97. doi: 10.1002/pro.667. Epub 2011 Jul 7.
4
Pentavalent Organo-Vanadates as Transition State Analogues for Phosphoryl Transfer Reactions.五价有机钒酸盐作为磷酰基转移反应的过渡态类似物
J Am Chem Soc. 2000 Oct 18;122(41):9911-9916. doi: 10.1021/ja0021058.
5
Triosephosphate isomerase: a highly evolved biocatalyst.磷酸丙糖异构酶：高度进化的生物催化剂。
Cell Mol Life Sci. 2010 Dec;67(23):3961-82. doi: 10.1007/s00018-010-0473-9. Epub 2010 Aug 7.
6
Shared traits on the reaction coordinates of ribonuclease and an RNA enzyme.核糖核酸酶与一种RNA酶反应坐标上的共同特征。
Biochem Biophys Res Commun. 2008 Jun 20;371(1):154-8. doi: 10.1016/j.bbrc.2008.04.036. Epub 2008 Apr 16.
7
Expression, purification from inclusion bodies, and crystal characterization of a transition state analog complex of arginine kinase: a model for studying phosphagen kinases.精氨酸激酶过渡态类似物复合物的表达、包涵体纯化及晶体表征：一种用于研究磷酸原激酶的模型
Protein Sci. 1997 Feb;6(2):444-9. doi: 10.1002/pro.5560060222.
8
The active site histidines of creatine kinase. A critical role of His 61 situated on a flexible loop.肌酸激酶的活性位点组氨酸。位于柔性环上的His 61的关键作用。
Protein Sci. 1997 Feb;6(2):331-9. doi: 10.1002/pro.5560060208.
9
Phosphinic peptide analogues as potent inhibitors of Corynebacterium rathayii bacterial collagenase.次膦酸肽类似物作为鼠棒状杆菌细菌胶原酶的有效抑制剂。
Biochem J. 1994 Oct 1;303 ( Pt 1)(Pt 1):323-7. doi: 10.1042/bj3030323.
10
Aldimine to ketoamine isomerization (Amadori rearrangement) potential at the individual nonenzymic glycation sites of hemoglobin A: preferential inhibition of glycation by nucleophiles at sites of low isomerization potential.血红蛋白A单个非酶糖基化位点上醛亚胺向酮胺的异构化（阿马多里重排）潜力：异构化潜力低的位点处亲核试剂对糖基化的优先抑制作用
J Protein Chem. 1991 Jun;10(3):345-58. doi: 10.1007/BF01025633.