Pharmacopsychiatry. 2011 Nov;44(7):344-6. doi: 10.1055/s-0031-1284425. Epub 2011 Oct 6.
Electroconvulsive therapy (ECT) is the most effective treatment for therapy-refractory depression. Usually, prior antidepressant medication will be continued during ECT. However, the seizure threshold may be influenced by psychotropic drugs. We report a patient who received right unilateral ECT under concomitant treatment with bupropion, a selective noradrenaline- and dopamine-reuptake inhibitor. After the fourth session, a focal status epilepticus occurred, which was pharmacoresistant for the duration of 12 days. We assume that the induction of a status may be facilitated by a lowering of the seizure threshold due to bupropion. An evaluation of drug therapy and control of EEG before and during ECT are recommended, especially when the drug treatment has an influence on the seizure threshold.
电抽搐治疗（ECT）是治疗抵抗性抑郁症最有效的方法。通常，在 ECT 期间会继续使用先前的抗抑郁药物。然而，抗惊厥药物可能会影响惊厥阈值。我们报告了一例在同时使用安非他酮（一种选择性去甲肾上腺素和多巴胺再摄取抑制剂）治疗的情况下接受右侧单侧 ECT 的患者。第四次治疗后，出现局灶性癫痫持续状态，持续 12 天对药物治疗无反应。我们假设安非他酮降低了惊厥阈值，从而促进了癫痫持续状态的发生。建议在进行 ECT 之前和期间评估药物治疗和脑电图控制，特别是当药物治疗对惊厥阈值有影响时。
