Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8732-8. doi: 10.1167/iovs.11-8302.
To investigate the relationship between neuroretinal rim (NRR) differential light absorption (DLA, a measure of spectral absorption properties) and visual field (VF) sensitivity in primary open-angle glaucoma (POAG).
Patients diagnosed with (n = 22) or suspected of having (n = 7) POAG were imaged with a multispectral system incorporating a modified digital fundus camera, 250-W tungsten-halogen lamp, and fast-tuneable liquid crystal filter. Five images were captured sequentially within 1.0 second at wavelengths selected according to absorption properties of hemoglobin (range, 570-610 nm), and a Beer-Lambert law model was used to produce DLA maps of residual NRR from the images. Patients also underwent VF testing. Differences in NRR DLA in vertically opposing 180° and 45° sectors either side of the horizontal midline were compared with corresponding differences in VF sensitivity on both decibel and linear scales by Spearman's rank correlation.
The decibel VF sensitivity scale showed significant relationships between superior-inferior NRR DLA difference and sensitivity differences between corresponding VF areas in 180° NRR sectors (Spearman ρ = 0.68; P < 0.0001), superior-/inferior-temporal 45° NRR sectors (ρ = 0.57; P < 0.002), and superior-/inferior-nasal 45° NRR sectors (ρ = 0.59; P < 0.001). Using the linear VF sensitivity scale significant relationships were found for 180° NRR sectors (ρ = 0.62; P < 0.0002) and superior-inferior-nasal 45° NRR sectors (ρ = 0.53; P < 0.002). No significant difference was found between correlations using the linear or decibel VF sensitivity scales.
Residual NRR DLA is related to VF sensitivity in POAG. Multispectral imaging may provide clinically important information for the assessment and management of POAG.
探讨原发性开角型青光眼（POAG）神经视网膜边缘（NRR）的差异光吸收（DLA，一种光谱吸收特性的测量）与视野（VF）敏感性之间的关系。
使用多光谱系统对 22 名被诊断患有 POAG（n=22）或疑似 POAG（n=7）的患者进行成像，该系统结合了改良的数字眼底相机、250W 钨卤素灯和快速调谐液晶滤波器。在 1.0 秒内连续捕获 5 张图像，波长根据血红蛋白的吸收特性选择（范围为 570-610nm），并使用 Beer-Lambert 定律模型从图像中生成剩余 NRR 的 DLA 图。患者还接受了 VF 测试。在水平中线两侧的 180°和 45°垂直相对象限中，NRR 的 DLA 差异与分贝和线性标度上相应 VF 区域的敏感性差异进行 Spearman 秩相关比较。
分贝 VF 敏感性标度显示，上/下 NRR DLA 差异与 180°NRR 象限中相应 VF 区域之间的敏感性差异之间存在显著关系（Spearman ρ=0.68；P<0.0001），上/下颞部 45°NRR 象限（ρ=0.57；P<0.002）和上/下鼻侧 45°NRR 象限（ρ=0.59；P<0.001）。使用线性 VF 敏感性标度，在 180°NRR 象限（ρ=0.62；P<0.0002）和上/下鼻侧 45°NRR 象限（ρ=0.53；P<0.002）中发现了显著关系。使用线性或分贝 VF 敏感性标度之间的相关性没有显著差异。
残留 NRR 的 DLA 与 POAG 的 VF 敏感性相关。多光谱成像可能为 POAG 的评估和管理提供重要的临床信息。
