Hybrid Computing Research Laboratory, Faculty of Engineering, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
Int J Nanomedicine. 2011;6:1757-64. doi: 10.2147/IJN.S23861. Epub 2011 Aug 23.
A novel design of a multi-drug delivery network and diagnosis using a molecular network is proposed. By using a pair of tweezers to generate the intense optical vortices within the PANDA ring resonator, the required molecules (drug volumes) can be trapped and moved dynamically within the molecular bus networks, in which the required drug delivery targets can be achieved within the network. The advantage of the proposed system is that the diagnostic method can be used within a tiny system (thin film device or circuit), which is available as an embedded device for diagnostic use in patients. In practice, the large molecular networks such as ring, star, and bus networks can be integrated to form a large drug delivery system. The channel spacing of the trapped volumes (molecules) within the bus molecular networks can be provided by using the appropriate free spectrum range, which is analyzed and discussed in the terms of crosstalk effects. In this work, crosstalk effects of about 0.1% are noted, which can be neglected and does not affect the network stability.
提出了一种使用分子网络进行多药物输送网络和诊断的新颖设计。通过使用一对镊子在 PANDA 环形谐振器内产生强光学涡旋，可以在分子总线网络内捕获和动态移动所需的分子（药物体积），从而在网络内实现所需的药物输送目标。所提出系统的优点在于诊断方法可以在微小系统（薄膜器件或电路）内使用，该系统可作为嵌入式设备用于患者的诊断用途。在实践中，诸如环、星和总线网络之类的大的分子网络可以被集成以形成大的药物输送系统。可以通过使用适当的自由光谱范围来提供总线分子网络内的捕获体积（分子）的通道间隔，并且以串扰效应的术语来分析和讨论该自由光谱范围。在这项工作中，注意到大约 0.1%的串扰效应，其可以忽略并且不影响网络稳定性。
