Alessandrini Andrea, Facci Paolo
Center; CNR-NANO-S3; Modena, Italy.
Commun Integr Biol. 2011 May;4(3):346-8. doi: 10.4161/cib.4.3.15073. Epub 2011 May 1.
Membrane protein activity is affected by the properties of the lipid bilayer hosting them. These properties are established by both the lipid composition and the thermodynamic state of the bilayer. In the latter case, any parameter that can alter the state of the bilayer is indirectly able to affect the activity of membrane proteins. In a recent study, we have demonstrated that the activity of the KcsA ion channel is strongly related to the thermodynamic state of the lipid bilayer. In particular, when the lipid bilayer is in its main phase transition region, the conductivity of KcsA is increased and all its characteristic times change according to the characteristic times of the lipid bilayer. We propose here that the lipid bilayer can affect the distribution among many conformational substates of the open channel, affecting the corresponding channel conductivity.
膜蛋白的活性受其所在脂质双层的性质影响。这些性质由脂质组成和双层的热力学状态共同决定。在后一种情况下，任何能够改变双层状态的参数都能间接影响膜蛋白的活性。在最近的一项研究中，我们证明了KcsA离子通道的活性与脂质双层的热力学状态密切相关。特别是，当脂质双层处于其主要相变区域时，KcsA的电导率会增加，其所有特征时间会根据脂质双层的特征时间发生变化。我们在此提出，脂质双层可影响开放通道多种构象亚态之间的分布，从而影响相应的通道电导率。
