Stojčić Milan, Hentova-Senćić Paraskeva, Stojčić Biljana
Srp Arh Celok Lek. 2011 Jul-Aug;139(7-8):428-32. doi: 10.2298/sarh1108428s.
The term glaucoma is used to cover a wide range of diseases, whose main feature is optic neuropathy. According to the level of intraocular pressure (IOP), the open angle glaucoma is arbitrarily divided into high tension glaucoma (HTG) and normal tension glaucoma (NTG).
The aim of this study was to investigate the differences of optic disc cup appearance between patients with NTG and HTG.
Prospective study included 30 patients (60 eyes) with NTG and 30 patients (60 eyes) with HTG. IOP was measured by Goldmann applanation tonometry. Examination of optic disc head was performed by indirect ophthalmoscopy with Volk 90 D superfield lens through a dilated pupil to observe qualitative and quantitative parameters. Visual fields were examined in all patients with the Octopus program G1, full threshold strategy (Octopus 500 EZ, Interzeag, Switzerland).
Vertical form of optic disc cup was present in 11 eyes with NTG (18.3%) and three eyes with HTG (5%) (p < 0.05). A disc with localized tissue loss (polar notching) on the inferior pole was observed in eight eyes with NTG (13.3%) and in one eye with HTG (1.7%) (p < 0.01). Uniformly enlarged, round cup was more frequent in patients with HTG than NTG: 93.3% and 68.3% respectively (p < 0.05).
The perceived differences indicate a complex multifactorial nature of glaucoma disease and a possible existence of two pathophysiological ways of optic disc changes within the same basic disease.
术语青光眼用于涵盖多种疾病,其主要特征为视神经病变。根据眼压(IOP)水平,开角型青光眼被随意分为高眼压性青光眼(HTG)和正常眼压性青光眼(NTG)。
本研究旨在调查NTG和HTG患者视盘杯外观的差异。
前瞻性研究纳入30例NTG患者(60只眼)和30例HTG患者(60只眼)。采用Goldmann压平眼压计测量眼压。通过间接检眼镜,使用Volk 90 D超大视野透镜经散瞳观察视盘头部,以观察定性和定量参数。所有患者均采用Octopus程序G1全阈值策略(Octopus 500 EZ,Interzeag,瑞士)进行视野检查。
NTG患者中有11只眼(18.3%)出现垂直型视盘杯,HTG患者中有3只眼(5%)出现(p<0.05)。在NTG患者的8只眼(13.3%)和HTG患者的1只眼(1.7%)中观察到下极有局限性组织缺失(极地切迹)的视盘(p<0.01)。HTG患者中均匀扩大的圆形视杯比NTG患者更常见:分别为93.3%和68.3%(p<0.05)。
观察到的差异表明青光眼疾病具有复杂的多因素性质,并且在同一基础疾病中可能存在两种视盘变化的病理生理途径。