VST Centre for Glaucoma Care, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
Brien Holden Institute of Optometry and Vision Science, Hyderabad Eye Research Foundation, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):889-900. doi: 10.1167/iovs.18-25421.
To compare the visual field (VF) progression among high tension glaucoma (HTG), primary angle closure glaucoma (PACG), and normal tension glaucoma (NTG) subjects in routine clinical care.
All patients had ≥5 VF tests using HFA, 24-2, SITA-standard strategy. We compared the progression between glaucoma subtypes after matching the VFs for baseline severity (mean deviation [MD]) and the age at presentation. Global VF progression was evaluated by linear regression analysis (LRA) of MD. For local VF progression, scotoma expansion (SE) defined as appearance of new scotoma and scotoma deepening (SD) defined by pointwise LRA were calculated. SE and SD were analyzed in three VF zones: superior arcuate (SA), inferior arcuate (IA), and central (C).
A total of 310 HTG, 304 PACG, and 165 NTG eyes were included. When VFs were matched by baseline MD, a greater number (n = 20/76) of eyes with HTG showed significant progression compared to PACG (n = 9/76; P = 0.04). The number of progressing eyes were not significantly different between HTG and NTG (n = 11/76; P = 0.10) and between NTG and PACG (P = 0.65). When the baseline VFs were matched by age, the number of eyes showing significant progression were similar in all the subtypes. SA zone in HTG and NTG showed greater SE and SD compared to other zones (P < 0.05), whereas IA zone in PACG showed greater SE and SD compared to other zones (P < 0.05).
In our cohort of treated primary glaucoma with matched baseline severity, a greater proportion of HTG eyes progressed faster compared to PACG. SA zone in HTG and NTG and IA zone in PACG showed greater VF progression.
比较常规临床护理中高压青光眼（HTG）、原发性闭角型青光眼（PACG）和正常眼压青光眼（NTG）患者的视野（VF）进展情况。
所有患者均使用 HFA 进行了≥5 次 VF 测试，采用 24-2、SITA-标准策略。我们通过线性回归分析（LRA）比较了在匹配基线严重程度（平均偏差[MD]）和发病年龄后，青光眼亚型之间的进展情况。通过 MD 的 LRA 评估全局 VF 进展。对于局部 VF 进展，计算了新暗点出现的暗点扩展（SE）和逐个点 LRA 定义的暗点加深（SD）。在三个 VF 区域（上弓形[SA]、下弓形[IA]和中央[C]）中分析 SE 和 SD。
共纳入 310 只 HTG、304 只 PACG 和 165 只 NTG 眼。当 VF 通过基线 MD 匹配时，与 PACG（n = 9/76）相比，更多的 HTG 眼（n = 20/76）显示出显著进展（P = 0.04）。HTG 和 NTG 之间进展眼的数量无显著差异（n = 11/76；P = 0.10）和 NTG 和 PACG 之间（P = 0.65）。当基线 VF 通过年龄匹配时，所有亚型中显示出显著进展的眼的数量相似。HTG 和 NTG 的 SA 区比其他区显示出更大的 SE 和 SD（P < 0.05），而 PACG 的 IA 区比其他区显示出更大的 SE 和 SD（P < 0.05）。
在我们的治疗原发性青光眼队列中，与基线严重程度匹配时，HTG 眼的进展速度比 PACG 眼更快。HTG 和 NTG 的 SA 区和 PACG 的 IA 区显示出更大的 VF 进展。
