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[胃原发性伯基特淋巴瘤]

[Primary Burkitt's lymphoma of the stomach].

作者信息

Colović Nataša, Radovanović Nebojša, Vidović Ana, Colović Milica

出版信息

Srp Arh Celok Lek. 2011 Jul-Aug;139(7-8):523-6. doi: 10.2298/sarh1108523c.

Abstract

INTRODUCTION

Burkitt's lymphoma belongs to the group of non-Hodgkin's lymphomas with B immunophenotypic features of lymphoma cells. It has tendency for extranodal localization primarily in the gastrointestinal tract and retroperitoneum. Primary Burkitt's lymphoma of the stomach is very rare. Stomach is most frequently involved secondarily, growing from intrabdominal tumorous mass into the stomach.

CASE OUTLINE

The authors present a 30-year-old male in whom after 6 months duration of temporarily melaenas the diagnosis of Burkitt's lymphoma was established by endoscopic examination and biopsy of ulceroinfiltrative lesion on the antral part of the stomach. The patient was in clinical stage IIE. After one cycle of chemotherapy according to protocol R-HyperCVAD, a subtotal distal gastrectomy and additional three cycles of the same chemotherapeutic protocol a complete remission was achieved.

CONCLUSION

Burkitt's lymphoma is a highly aggressive non-Hodgkin's lymphoma often present in extranodal sites. It should be treated with systemic intensive chemotherapy and surgical removal of tumorous mass when possible. Long-term survival using the combination therapy is possible to achieve in 40-80% of patients.

摘要

引言

伯基特淋巴瘤属于具有淋巴瘤细胞B免疫表型特征的非霍奇金淋巴瘤组。它倾向于结外定位,主要位于胃肠道和腹膜后。原发性胃伯基特淋巴瘤非常罕见。胃最常继发受累,从腹腔内肿瘤块向胃生长。

病例概述

作者报告一名30岁男性,在持续6个月的间歇性黑便之后,通过内镜检查和胃窦部溃疡性浸润病变活检确诊为伯基特淋巴瘤。患者处于临床IIE期。按照R-HyperCVAD方案进行一个周期化疗后,行远端胃次全切除术,并继续进行相同化疗方案的另外三个周期,实现了完全缓解。

结论

伯基特淋巴瘤是一种高度侵袭性的非霍奇金淋巴瘤,常出现在结外部位。应采用全身强化化疗,并尽可能手术切除肿瘤块。联合治疗可使40%-80%的患者获得长期生存。

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