Department of Pathology and Laboratory Medicine; McMaster University, Hamilton, Ontario, Canada.
J Gastrointestin Liver Dis. 2009 Mar;18(1):99-101.
Epithelioid cell granulomas are more commonly seen in Hodgkin's disease and T cell lymphomas. Rarely florid granulomatous reaction with necrosis may be a prominent feature in lymphoma. To the best of our knowledge, a total of 11 cases of Burkitt's lymphoma with florid necrotizing granulomas have been reported in the English literature. None of these cases have previously had the stomach involved. Here we report a gastric Burkitt's lymphoma with florid granulomatous reaction diagnosed following a partial gastrectomy. The initial gastric biopsy showed granulomatous gastritis but the radiological and endoscopic appearance was that of a gastric stromal tumour. We conclude that in the presence of a mass lesion, the finding of epithelioid granulomas should warrant re-biopsy to establish an accurate diagnosis and exclude a concurrent malignant process. Hence, major surgery and postoperative complications can be avoided and appropriate treatment regimen can be initiated.
上皮样细胞肉芽肿更常见于霍奇金病和 T 细胞淋巴瘤。在淋巴瘤中,罕见的弥漫性粒状坏死反应可能是一个突出的特征。据我们所知,在英文文献中总共报道了 11 例伴有弥漫性坏死性肉芽肿的伯基特淋巴瘤。这些病例以前均无胃部受累。在此,我们报告了一例胃伯基特淋巴瘤,表现为弥漫性粒状反应,经部分胃切除术诊断。最初的胃活检显示为肉芽肿性胃炎,但影像学和内镜表现为胃间质瘤。我们的结论是,在存在肿块病变的情况下,上皮样肉芽肿的发现应进行再次活检以确立准确的诊断并排除并发的恶性过程。因此,可以避免大手术和术后并发症,并可以启动适当的治疗方案。