Taşçilar Mehmet Emre, Cekmez Ferhat, Meral Cihan, Pirgon Ozgür, Tanju I A, Canpolat Fuat Emre, Abaci Ayhan, Tapan Serkan, Eker Ibrahim
Department Pediatrics, Gülhane Military Medical Academy, Ankara, Turkey.
Turk J Pediatr. 2011 May-Jun;53(3):269-73.
Obesity and overweight are among the most serious health problems in western societies and an increasing problem in developing countries. Recent studies indicate an important role of adipose tissue hormones, or "adipokines", in obesity-associated complications. To investigate the relation of two circulating adipokines (visfatin, adiponectin) with markers of insulin sensitivity and obesity in children, 40 obese children and 40 control children were recruited. Homeostasis model assessment for insulin resistance (HOMA-IR) and visfatin levels (4.99 +/- 2.08 vs. 1.47 vs. 0.7, p < 0.001; 31.3 +/- 11.1 vs. 18.5 +/- 10.7, p < 0.001, respectively) were significantly elevated and adiponectin levels (2.01 +/- 1.02 vs. 12.5 +/- 6.2, p < 0.001) were significantly lower in the obese group. Comparisons of the clinical and metabolic characteristics between insulin-resistant and noninsulin-resistant groups in obese children are summarized. The insulin-resistant group had higher visfatin levels (36 +/- 9.7 vs. 22.9 +/- 7.6, p < 0.001) and lower adiponectin levels (1.7 +/- 1.05 vs. 2.5 +/- 0.77, p: 0.016). Visfatin was correlated positively and adiponectin was correlated negatively with body mass index standard deviation score (BMI-SDS) and HOMA-IR. The role of various adipokines as connectors between obesity and diabetes mellitus has been better elucidated in recent years. Based on the findings of this study, visfatin and adiponectin levels can be used as specific markers for insulin sensitivity.
肥胖和超重是西方社会最严重的健康问题之一，且在发展中国家也日益成为一个问题。最近的研究表明，脂肪组织激素或“脂肪因子”在肥胖相关并发症中起着重要作用。为了研究两种循环脂肪因子（内脂素、脂联素）与儿童胰岛素敏感性和肥胖指标之间的关系，招募了40名肥胖儿童和40名对照儿童。肥胖组的胰岛素抵抗稳态模型评估（HOMA-IR）和内脂素水平（分别为4.99±2.08对1.47对0.7，p<0.001；31.3±11.1对18.5±10.7，p<0.001）显著升高，而脂联素水平（2.01±1.02对12.5±6.2，p<0.001）显著降低。总结了肥胖儿童中胰岛素抵抗组和非胰岛素抵抗组的临床和代谢特征比较。胰岛素抵抗组的内脂素水平较高（36±9.7对22.9±7.6，p<0.001），脂联素水平较低（1.7±1.05对2.5±0.77，p：0.016）。内脂素与体重指数标准差评分（BMI-SDS）和HOMA-IR呈正相关，脂联素与它们呈负相关。近年来各种脂肪因子作为肥胖和糖尿病之间联系因素的作用已得到更好的阐释。基于本研究的结果，内脂素和脂联素水平可作为胰岛素敏感性的特异性标志物。
