Department of Biochemistry, Ziauddin University, 4/B, Shahrah-e-Ghalib, Block 6, Clifton, Karachi 75600, Pakistan.
Biomark Med. 2013 Oct;7(5):731-5. doi: 10.2217/bmm.13.41.
Childhood obesity is a global epidemic and is associated with a higher risk of chronic diseases such as hypertension, diabetes mellitus and other metabolic disorders. Several adipokines including resistin, visfatin, leptin and adiponectin are synthesized and secreted by adipocytes, which play an important role in obesity.
PATIENTS & METHODS: A total of 90 subjects (60 controls and 30 obese) between the ages of 5 and 18 years were selected. Serum visfatin, TNF-α, resistin, insulin and adiponectin were measured using ELISA and insulin resistance was calculated by the Homeostasis Model of Assessment-Insulin Resistance.
Mean ± standard deviation Homeostasis Model of Assessment-Insulin Resistance, serum TNF-α and visfatin levels were significantly higher in obese subjects (3.99 ± 0.94, 12.99 ± 3.42, 10.89 ± 2.72, respectively) compared with the control group (1.60 ± 0.34, 7.22 ± 2.22 and 4.97 ± 1.57, respectively). Mean ± standard deviation serum adiponectin levels were significantly lower in obese children (5.95 ± 1.02) compared with controls (9.07 ± 1.25). Binary logistic regression shows that adiponectin and visfatin are associated with obesity.
Circulating levels of adipokines vary in obesity and adiponectin and visfatin are associated with obesity.
儿童肥胖是一种全球性的流行病，与高血压、糖尿病和其他代谢紊乱等慢性病的风险增加有关。几种脂肪因子，包括抵抗素、内脂素、瘦素和脂联素，由脂肪细胞合成和分泌，在肥胖中起着重要作用。
选择了 90 名年龄在 5 至 18 岁之间的受试者（60 名对照组和 30 名肥胖组）。采用 ELISA 法测定血清内脂素、TNF-α、抵抗素、胰岛素和脂联素水平，用稳态模型评估胰岛素抵抗计算胰岛素抵抗指数。
肥胖组的稳态模型评估胰岛素抵抗指数、血清 TNF-α和内脂素水平的平均值±标准差分别为 3.99±0.94、12.99±3.42 和 10.89±2.72，明显高于对照组的 1.60±0.34、7.22±2.22 和 4.97±1.57。肥胖儿童的血清脂联素水平的平均值±标准差明显低于对照组（5.95±1.02 和 9.07±1.25）。二元逻辑回归显示，脂联素和内脂素与肥胖有关。
循环脂肪因子水平在肥胖中有所不同，脂联素和内脂素与肥胖有关。
